Reading outside his research area and efficient chemistry helped 2022 Perkin Medal winner Dennis Liotta develop groundbreaking drugs.

There has been an explosion of statistics in football, but one of the most influential figures in this revolution, Ramm Mylvaganam, didn’t care for the game. He worked for the confectionary company Mars. He sold chairs. He knew nothing about football.

However, this key figure outlined in Rory Smith’s recent book, Expected Goals: The story of how data conquered football, came into the field of football analysis and changed the game forever – partly because he approached the game with the fresh perspective of the outsider.

So, what do football statistics have to do with a chemist who came up with life-saving medications? Well, Dr Dennis Liotta, who came up with AIDS antivirals that have saved thousands of lives, may not have entered medicinal chemistry as a complete outsider. He was a chemist, after all. However, like Ramm Mylvaganam, his broad breadth of knowledge from different areas gave him a unique perspective on a new field.

Reading at random

Dr Liotta didn’t take the standard path into medicinal chemistry. In fact, he wasn't a diligent chemistry student at first – and that, in an odd way, contributed to his later success.

For the first couple of years at university, he was more interested in his extracurricular activities; but in his third year, he realised he needed to catch up. He worked hard and burnt the midnight oil. He also did something unusual.

‘I did something that’s kind of ridiculous-sounding,’ he said. ‘I had this big fat organic chemistry book, and I would just open it up randomly to some page and read 10 or 12 pages and close it back up. Over time, I ended up covering not only the things I missed, but actually learning about a lot of things that wouldn't have been covered.’

As his career progressed, Dr Liotta realised the importance of not just working harder, but working smarter. On Sundays, he would sit down with a bunch of academic journals to stay abreast of developments. However, as he read them, he discovered other papers – ones outside his research area – that piqued his interest.

Dennis Liotta in one of his lab spaces at Emory. Image by Marcusrpolo.

‘I’d see something intriguing. And so I’d say, that’s interesting, let me read. I started learning about things that I didn’t technically need to know about, because they were outside of my immediate interest. But those things really changed my life. And, ultimately, I think they were the differentiating factor.’

The intellectual stretch

This intellectual curiosity led to more than 100 patents, including a groundbreaking drug in the fight against AIDS that is still used today and a hand in developing an important hepatitis C drug.

‘In science, many times the people who actually make the most significant innovations are the people who come at a problem that’s outside of their field,’ Dr Liotta said. ‘Without realising it, we all get programmed in terms of how we think about problems, what we accept as fact.’

‘But when you come at a problem that’s outside your field… you aren't immersed in it. So, you think about the problems differently. And many times, in thinking about the problems differently, you’ll come up with an alternative solution that people in the field wouldn’t.’

We’ve often heard the stories of Steve Jobs wandering into random classes while at university when he should have been attending his actual course. Apparently, a calligraphy class inspired the font later used in Apple’s products. In other words, early specialism can sometimes hinder creativity.

‘I've looked into people who have made really some amazing contributions, and many times there’s been an intellectual stretch,’ Dr Liotta said. ‘They’ve gone out there and done something that they weren’t really trained to do. You can fall on your face from time to time, but it’s really nice when we're able to make contributions in areas where we don’t really have any formal training.’

Chance favours…

Of course, there’s so much more to creating life-saving drugs than intellectual curiosity and a different way of thinking. Dr Liotta and his colleagues had the technical skill to turn their ideas into something real. He was a skilled chemist who teamed up with an excellent virologist, Raymond Schinazi. The result of this blend of their skills gave them an edge over others developing AIDS therapeutics.

Dr Liotta invented breakthrough HIV drug Emtricitabine.

‘The very first thing we did was we figured out a spectacular way of preparing the compounds – very clean, very efficient,’ he said. ‘And that [meant we could] explore all sorts of different permutations around the series of compounds that others couldn’t easily do, because their methods were so bad for making [them].

‘So, even though we were competing against some very important pharmaceutical companies that had infinitely more money than we had – dozens of really smart people they put on the project – we were able to run circles around them because we had a really efficient methodology and that enabled us to make some compounds.’

The amazing thing is that the very first compound and the third compound the pair came up with led to FDA-approved drugs. It is a fine thing, indeed, when skill and serendipity meet.

‘Chance favours the prepared mind,’ Dr Liotta said, ‘or, as my colleagues say: you work hard to put yourself in a position to get lucky.’

>> Learn more about Dr Liotta’s career path and research from our recent Q&A.

There is still work to be done to redress racial inequality in chemistry, and across science in general, but relatable role models can have a positive influence on the next generation.

Homophily. Ever heard of it? Me neither, until 30 minutes ago. Homophily basically means that we are more likely to connect with people who are similar to us in some way.

In work terms, homophily could be a relatable role model. So, as an Irish science writer, I admire Flann O’Brien for his ability to decongest complicated subjects with such wit and flair (not so much for hiding whiskey in the toilet during interviews). For a young chemist, a role model could be someone from a similar background who excels in a job she or he would love to have.

But what happens if you just don’t see relatable role models in your chosen field? What if systemic failings make the profession less attractive and harder to trace the path to success?

Unfortunately, systemic failings, the relative lack of homophily, and pervasive inequality were among the findings of Missing Elements – Racial and ethnic inequalities in the chemical sciences, a report released by the Royal Society of Chemistry (RSC) in March.

The report highlighted the barriers facing Black chemists in the UK, and it certainly didn’t hold back. In the Foreword, Dr Helen Pain, RSC’s Chief Executive, said: ‘The data and evidence collected in this report are clear: we are failing to retain and nurture talented Black chemists at every stage of their career path after undergraduate studies.’

The report found that just 1.4% of postgraduate students, 1% of non-academic chemistry staff, and 0% of chemistry professors are Black. It added that Black chemists face barriers in industry too, and that people from minoritised communities are under-represented at senior levels across the workforce.

It proceeded to mention six themes that affect the retention and progression for Black chemists, including the impact of homophily, which it defined as ‘the tendency for people to form connections with people similar to themselves.’

The importance of mentors

When I read that, a little bell chimed in my head. When my colleague Muriel Cozier interviewed three eminent Black chemists last year – Cláudio Lourenço, Jeraime Griffith, and Dr George Okafo – each mentioned the need for relatable role models to increase the representation of Black chemists.

When she asked Cláudio about specific impediments that prevent young Black people from pursuing chemistry, he said: ‘I think one of the biggest barriers that prevent people from pursuing careers in science is the lack of role models. If we only show advertisements for chemistry degrees with White people, it’s not encouraging for Black students to pursue a career there.

‘The same goes for when we visit universities; role models are needed. No one wants to be the only Black person in the department. Universities need to embrace diversity at all levels.’

George made a similar point. He emphasised the need for young chemists to surround themselves with mentors. ‘I think it is important to look for role models from the same background to help inspire you.’ When Muriel asked him which steps could be taken to increase the number of Black people pursuing chemistry as a career, he added: ‘Have more role models from different backgrounds. This sends a very powerful message to young people studying science reinforcing the message… I can do that!’

When asked about his message for Black people following in his footsteps, Jeraime said: ‘Seek out mentors, regardless of race, who can help you get there. Don’t be afraid to email them and briefly talk about your interest in the work they’ve done, what you have done, and are doing now.’

Jeraime also cited lack of representation as a barrier that prevents more young Black people from entering chemistry. ‘Lack of representation I think is the number one barrier,’ he said. ‘Impostor syndrome is bad at the best of times, but worse still if there’s no representation in the ivory tower.’

The issue of inequality in chemistry is large – far too large for a mere 752-word blog – but as we celebrate the achievements of Black chemists everywhere this week, it is clear just how much of a positive influence role models such as Cláudio, George, Jeraime, and countless others can have on the dreams and aspirations of young chemists.

>> Here are Cláudio’s, Jeraime’s, and George’s stories.

Written by Eoin Redahan and based on previous reporting by Muriel Cozier.

Image by Damien Walmsley.  

The Commonwealth Games has landed in Birmingham. Before the Games began, viewers were treated to an extraordinary opening ceremony (featuring a giant mechanical bull) and its artistic director, Iqbal Khan, was lauded for his ingenuity.

But such ingenuity shouldn’t surprise any of us, for Birmingham has long been a place of outsized invention. For more than 300 years, the inhabitants of this industrial powerhouse have churned out invention after invention; and its great pragmatists have turned patents into products.

Chemistry, too, owes a debt to the UK’s second city. Whether it’s the first synthesis of vitamin C, the invention of human-made plastic, adventures in mass spectrometry, or electroplated gold and silver trinkets, Birmingham has left a lasting legacy.

Here are five chemists whose innovations may have made an appearance in your life.

Alexander Parkes – man of plastic

Plaque commemorating Alexander Parkes in Birmingham, England. Image by Oosoom

Look around you. Look at the computer screen, the mouse button you click, and the wire casings everywhere. Someone started it all. That man was Alexander Parkes, inventor of the first human-made plastic.

The son of a brass lock manufacturer from Suffolk Street, Birmingham, Parkes created 66 patents in his lifetime including a process for electroplating delicate works of art. However, none were as influential as the 1856 patent for Parkesine – the world’s first thermoplastic.

Parkes’ celluloid was based on nitrocellulose that had been treated by different solvents. In 1866, he set up the Parkesine Company at Hackney Wick, London, but it floundered due to high cost and quality issues. The spoils of his genius would be enjoyed by the rest of us instead.

Sir Norman Haworth – the vitamin seer

Sir Norman Haworth

Sir Norman Haworth may have been born in Chorley, Lancashire, but his finest work arguably came after he became Director of the Department of Chemistry in the University of Birmingham in 1925. Haworth is famous for his groundbreaking carbohydrate investigations and for being the first to synthesise vitamin C.

By 1928, Haworth had confirmed the structures of maltose, cellobiose, lactose, and the glucoside ring structure of normal sugars, among other structures. Apparently, his method for determining the chain length in methylated polysaccharides also helped confirm the basic features of starch, cellulose, and glycogen molecules.

However, Haworth is most famous for determining the structure of vitamin C and for becoming the first to synthesise it in 1932. The synthesis of what he called ascorbic acid made the commercial production of vitamin C far cheaper – the benefits of which have been felt by millions of us.

For his achievements in carbohydrates and vitamin C, Haworth received the Nobel Prize for Chemistry in 1937 (shared with Paul Karrer). He was the first British organic chemist from the UK to receive this honour. Haworth even had a link to SCI, having been a pupil of William Henry Perkin Junior in the University of Manchester’s Chemistry Department.

Francis William Aston – adventures in mass spectrometry

Blue plaque for Francis William Aston. Image from Tony Hisgett

Another Nobel Prize-winning chemist from Birmingham is Francis William Aston. The Harborne native won the 1922 prize for discovering isotopes in many non-radioactive elements (using his mass spectrograph) and for enunciating the whole number rule.

For a time, academia almost lost Aston, as he spent three years working as a chemist for a brewery. Thankfully, he returned to academic life and obtained concrete evidence for the existence of two isotopes of the inert gas neon before the first World War.

After working for the Royal Aircraft Establishment during the Great War (1914-18), he resumed his studies. The invention of the mass spectrograph proved pivotal to his discoveries thereafter. Using this apparatus, he identified 212 naturally occurring isotopes.

George Elkington and John Wright – all that glitters

George Elkington patented the electroplating process developed by John Wright. Image from Spudgun67

It isn’t surprising that George Elkington should become an SCI favourite, as he blended both scientific ingenuity with business. The son of a spectacle manufacturer patented the first commercial electroplating process invented by Brummie surgeon John Wright in 1840.

Wright discovered that a solution of silver in potassium cyanide was useful for electroplating metals. Elkington and his cousin Henry purchased and patented Wright’s process before using it to improve gold and silver plating.

The Elkingtons opened an electroplating works in the city’s now famous Jewellery Quarter where they electroplated cutlery and jewellery. And they didn’t do too badly out of it. By 1880, the company employed 1,000 people in seven factories.

Alfred Bird – winging it

1906 advertisement for Birds Custard powder. Image from janwillemsen

In 1837, Alfred Bird was in a pickle. He wanted to serve his dinner party guests custard, but his wife was allergic to eggs and yeast, and egg was the main thickening agent of this delicious gloop.

Instead of serving something else, the chemist shop owner invented his own egg-free custard by substituting cornflour for eggs. His guests found it delicious and Bird’s Custard was born.

Not content with this innovation, Bird is also credited with being the father of modern baking powder. Once again, his wife’s allergies were said to be the inspiration, as he wanted to create a yeast-free bread for her. In bread and custard, true love always finds a way.

Paulina Quintanilla has developed a clever way to maximise the froth flotation technology used to extract more valuable minerals from rocks. The SCI Scholar and Poster Competition winner chatted to us about her process and how it could make mineral processing more efficient.

How would you describe your froth flotation technology in simple terms?

Froth flotation is the most widely used technology to separate valuable mineral particles from waste rock. The process is carried out in stirred tanks in which chemical reagents and air are added. Some of these reagents, called collectors, make the valuable mineral particles hydrophobic, which means that they repel water.

Consequently, the valuable mineral particles attach to the air bubbles, covering them and generating bubble-particle aggregates. The bubble-particle aggregates rise to the top of the tank, forming a froth that overflows as a mineral-rich concentrate, while the waste rock leaves from the bottom of the tank as tailings.

Froth flotation is also relevant in several other industrial applications, such as water treatment and paper de-inking.

Schematic of the froth flotation process. Image by @AMPRG_Imperial.

How would you describe your froth flotation technology in simple terms?

This research focuses on optimising the froth flotation process using a control strategy called model predictive control. To this end, mathematical models were developed to represent the phenomena inside a flotation tank. These models are then used to ‘predict the future’ so that decisions can be taken now (we can control the process) to improve the froth flotation performance.

Model predictive control is a powerful optimisation strategy that has been widely used in other processes, including in the petrochemical industry, but it is still very new in the mineral processing industry.

One of the main advantages of this research is that the models are physics-based. This means that they were developed from the fundamental physics of the process rather than from data, which makes them useful under any operating conditions, for any flotation tank size. This is particularly interesting for application in the large flotation tanks used on an industrial scale.

How could this work benefit industry and make processing more efficient?

Building clean technologies for the transition to 100% green energy is creating a massive demand for a range of minerals. For example, copper mines would have to ramp up production considerably to satisfy the extra 7% predicted demand. Meeting that demand, however, is becoming more and more challenging as ores are becoming lower grade, deeper, and more complex.

This implies that there is an urgent need to optimise current processes to extract the necessary minerals and metals more sustainably and efficiently. As froth flotation is a large-scale process, even small improvements in the separation efficiency would translate into important increments in production.

Overflowing froth seen from the top of an industrial-scale tank. Image by @AMPRG_Imperial.

We demonstrated that improvements of between 8 to 22% in metal recovery were achieved by implementing a model predictive control strategy at the laboratory scale, revealing an untapped potential for implementation at an industrial scale. This research could serve as a promising next step for the mining industry to meet future metal and mineral demands by extracting more metal for the same amount of resources, such as water, energy, and chemicals.

>> Interested to find out more about SCI Scholarships?

Your flotation tanks are actually based in Chile. How do you operate them remotely?

I am currently implementing an online model predictive control strategy in a laboratory-scale flotation bank in Chile. I monitor and control this experimental rig from home, in the UK.

The experimental rig was automated in such a way that all the instruments (e.g. air flow meters, controllers, pumps, etc.) are connected to a module called ‘Programmable Logic Controller’. This module is then connected to a workstation computer, which I access from my laptop in the UK.

The Programmable Logic Controller allows me to obtain measurements in real-time and control the system. In this case, the measurements are used to update the mathematical models, while the system is controlled by changing the ‘revolutions per minute’ of the pumps (to change the pulp levels) and/or moving the air valves (to change the airflow rates).

Experimental campaign in 2018 – aerial view of a 300m³ froth flotation tank. Image by @AMPRG_Imperial.

Could this process be used to extract other materials? If so, which ones?

While froth flotation is widely used to separate sulphide minerals of copper, it is also used to separate other sulphides, such as those containing lead, zinc, and molybdenum.

You won an SCI Scholarship. How did you use the funds you received to develop your research?

I used the generous SCI scholarship to partially fund a two-month visit to the laboratory in Chile. I set up new connections for remote control by installing new instrumentation to make it even more automated, and I carried out preliminary online control experiments. Since then, all the control experiments have been carried out from my laptop at home.

I also used the scholarship to fund my participation in several conferences, including one in person in Athens, Greece, in 2021. I have participated in Scholar Days in 2020 and 2021, in which I presented advances in my PhD research to a wide audience. This year, I presented my PhD research results at SCI headquarters for the first time and participated in the Poster Showcase, where I won first place.

Paulina presenting at the SCI Scholars' Showcase in July 2022. Image: SCI/Andrew Lunn

What are your future plans for this innovative technology (and other potential research)?

I plan to keep up the momentum of researching froth flotation optimisation, as I believe that there is still a long way to go for improvement, particularly at an industrial scale. Model predictive control has not been widely explored within the mineral processing industry despite the fact that it has shown great potential. There is still a gap between academia and industry that should be bridged, sooner rather than later, to improve the performance of the process.

Apart from the model predictive control strategy using physics-based models (including the one I have investigated during my PhD research), many other control strategies show great potential to be tested and implemented at an industrial scale.

This is particularly applicable in mineral processing plants, as most of them collect a huge amount of data that could serve as valuable inputs for further improvement and optimisation, using novel engineering tools such as artificial intelligence and digital twins.

Paulina is part of the Advanced Mineral Processing Research Group at Imperial College London, whose research includes fluid dynamics of flotation tanks and multi-criteria decision-making for sustainable mining and mineral processing.

A range of greenhouse gas removal technologies may be necessary if we’re to reach Net Zero by 2050. In the second of our two-part geoengineering feature, Eoin Redahan looks to the sea, the sun, and mineral weathering, and at the ethical concerns such technologies raise. Missed Part One? Find it here.

‘Water, water, everywhere, nor any drop to drink.’

These famous words from Samuel Taylor Coleridge’s Rime of the Ancient Mariner aren’t the only famous part of his epic poem. The term albatross around one’s neck comes from it too.

After shooting a friendly albatross at sea, the poem’s narrator was forced by the ship’s crew to wear the dead creature around his neck – and grievous luck was to follow. Well, our blue planet has an albatross around its neck in the form of climate change.

Perhaps the solution to it lies all around us – water, water, everywhere…

An ocean of potential

In theory, we can use our oceans to pull CO₂ from the air on an enormous scale. All it may take is clever intervention – potentially ruinous, albatross-shooting intervention.

Nevertheless, the World Economic Forum lays out the tantalising potential. ‘Ocean-based CO₂ removal can help us achieve “net negative emissions” as the seas hold 50 times more carbon than the atmosphere,’ it says.

‘The ocean [is] a sink for nearly one third of anthropogenic carbon emissions and more than 90% of the resulting heat… If we are going to manage atmospheric CO₂ levels to our advantage, we will need to leverage the ocean’s existing ability to govern the global carbon cycle.’

Frontier has targeted the development of scalable sources of alkalinity. The reasoning behind it is that with CO₂ being an acidic molecule, rising CO₂ concentrations could be neutralised through alkalinity. It has mentioned using mine tailings to remove up to 0.5 gigatonnes of CO₂ from the air each year; but the major caveat here is that it needs to be done safely.

Planetary Technologies has ventured into this space armed, essentially, with a bicarbonate of baking soda that could draw in CO₂ and sequester it for millenia.

The company explains its process: ‘We start by carefully extracting key parts of the mine tailings including recovering battery metals (like nickel and cobalt) and silica (sand) and then take the remaining purified metal salt solution into a special electrolyser. There, using clean, renewable electricity, the salt and water are split to make hydrogen (a clean, emissions-free fuel), and a pure alkaline hydroxide.

‘It’s from this point that we transport the bulk alkaline materials to our ocean outfalls site where the alkalinity is introduced to the surface ocean that then draws in CO₂, sequestering it as already abundant bicarbonate and carbonate ions in seawater.’

So, by decreasing the acidity of the ocean, it would have a greater capacity to absorb CO₂ from the air. The key, however, is to reduce this to a viable price point.

>> Want to read about iron fertilisation in our oceans? Rhiannon Garth Jones took a closer look here.

Mineral weathering, methane capture, and more

Mineral weathering is another contender in the CO₂ removal mix. One technology that recently received $2.4m in funding is Seattle-based Lithos’ enhanced weathering process – a mineral weathering process that could capture CO₂ at a gigatonne scale. According to Frontier, Lithos spreads basalt on croplands to increase dissolved organic carbon, before eventually being stored as ocean bicarbonate. The idea is to maximise CO₂ removal while bolstering crop growth.

Closer to home, SAC Consulting in Edinburgh will receive £2.9m to capture the methane produced by cattle and cut emissions from the livestock farming sector; Synthetic Biology in San Francisco has received an R&D grant to synthesise a polymer within algae that is capable of sequestering atmospheric CO₂ at a large scale; and Charm Industrial is converting plants into a carbon-rich liquid that is pumped underground.

To do the latter, Charm grows cellulosic biomass that captures CO₂ from the atmosphere. It is then harvested, ground, and heated, before being turned into a bio-oil that is pumped underground.

Even the concrete beneath our feet could be used as a carbon sink. CarbonCure is injecting CO₂ into its concrete mixes, which it says is not only comparable in cost to traditional concrete, but stronger.

And then, we have solar engineering – arguably the first technology that comes into many of our minds when we think of carbon removal. All sorts of geoengineering technologies exist in this sphere including cirrus cloud thinning, stratospheric aerosol scattering, and marine cloud brightening.

Ethical issues?

Interestingly, Harvard’s Solar Geoengineering Research Programme referred to geoengineering as ‘a set of emerging technologies that could manipulate the environment and partially offset some of the impacts of climate change’.

Therein lies the problem for many. What are the consequences of ‘manipulating the environment’, especially if these technologies fall into unscrupulous hands?

In her excellent blog for SCI on geoengineering, Rhiannon Garth-Jones referred to the Haida Corporation Salmon trial. In this trial, 120 tonnes of iron compound were deposited in the migration routes of pink and sockeye salmon in the Pacific Ocean, which resulted in a several-month-long phytoplankton bloom.

It was seen by many as a success. The phytoplankton fed fish and increased biodiversity and the iron sequestered carbon; but Environment Canada believed the corporation violated national environmental laws by depositing iron without a permit.

History teaches us that profit vs. planet tussles don’t always go the way we would like, and the consequences of these technologies going into the wrong hands could be catastrophic.

On 29 June, The World Economic Forum called for a code of conduct for ocean-based CO₂ removal; and the American Geophysical Union, a group of climate and planetary scientists, is leading the way in developing an ethical framework for climate intervention engagement.

We’re all feeling the effects of climate change. As I write this piece on 19 July, it is 39°C here in Greenford, London. 39°C in London! The earth is cracking, planes are circling (because the runways are melting), and grass fires are blazing in Croydon.

On days like today, it feels like we need all the innovation we can get.

From the Black Death to the Covid-19 pandemic, great adversity has also led to great advances. So, which inventions have emerged from times of hardship? Eoin Redahan finds out.

‘World events shape innovations. The World Wars shaped innovation, and the pandemic has shaped innovation,’ said Paul Booth OBE, in his outgoing speech as SCI President.

‘It is possible to accelerate innovation – we’ve demonstrated that.’ Paul Booth OBE, outgoing SCI President at SCI’s AGM, July 2022. Image: SCI/Andrew Lunn

The pandemic taught us a lot about ourselves. It taught me that eating my body weight in sweets was a great way to destroy my teeth, and it brought home to many the futility of the five-day commute. On a more abstract level, it taught governments and policy makers just how much can be achieved in a short space of time when necessity demands it. The vaccines that swam around our veins bore testament to this.

The pandemic has shaped innovation. Nowhere is this more apparent than in medicine. It isn’t the first awful event to provide a hotbed for change, and it won’t be the last. ‘It is possible to accelerate innovation,’ Paul said. ‘We’ve demonstrated that.’

Black Death and the bird mask

As bad as the Covid-19 pandemic was, the Black Death makes it look very tame indeed. It is estimated that the Plague, which was its worst from 1346-53, took up to 200 million lives in Eurasia and North Africa.

Amid the carnage, it is also said to have given us a system to mitigate infectious diseases with which we are familiar, including isolation periods. According to Britannica, ‘public officials created a system of sanitary control to combat contagious diseases, using observation stations, isolation hospitals, and disinfection procedures.’

The terrifying doctor will see you now.

The Plague also said to have inspired greater experimentation in pharmacology. In a sense, it also helped democratise medicine, with medical textbooks shifting from Latin to the vernacular. As John Lienhard, at the University of Houston, noted: ‘Both medical and religious practice now shifted toward the laity.’

But perhaps the most memorable advance from this time was the strange, beak-like masks worn by some doctors during the Plague. These masks were a crude (and frankly terrifying) way to protect the doctors from the disease in the air. The doctors even filled these masks with herbs in an effort to protect against pathogens.

Byproducts of the war effort

Of course, wars have also led to military innovation at breakneck speed. During the American Civil War, the Minié ball was created. It spun faster than other bullets and could travel half a mile – unlike pre-Civil War bullets, which went a mere 300 feet.

Officers of a monitor-class ironclad warship, photographed during the American Civil War.

This war also led to the ironclad warship, with plates riveted together to protect against cannonballs. However, it should also be noted that many of the most interesting war-borne inventions have ended up having little or nothing to do with military application.

The ‘cotton-like-texture’ of cellucotton led to its brand name Kotex. According to this 1920 advertisement, this ‘wardrobe essential of Her Royal Daintiness’ was available at any shop that catered to women. Different times.

World War I gave us the blood bank, the Kleenex, the trench coat, and the sanitary pad. The sanitary pad has peculiar origins. In 1914, the war resulted in cotton shortages and substitutes were needed. Kimberly-Clark executives duly discovered a processed wood pulp material that was five times more absorbent than cotton, and cheaper to make. The material was used for bandages, and Red Cross nurses realised that this material could be used as makeshift sanitary pads. The company then developed a sanitary pad – branded Kotex – made from cellucotton and a fine gauze.

Synthetic rubber and Super Glue

Material substitution also led to ground-breaking innovation in World War II. According to the National WWII Museum New Orleans, in 1942 Japan cut off the US supply of natural rubber. With the demand for rubber high, US President Franklin Roosevelt invested $700m to make synthetic rubber from petrochemical byproducts at 51 new plants. By 1944, these synthetic rubber plants were producing 800,000 tonnes of the material a year.

Duct tape was developed by Johnson & Johnson during the Second World War, and by 1972 the ubiquitous tape had reached the moon. This makeshift wheel fender repair helped the Apollo 17 mission’s lunar rover to keep lunar dust at bay.

We use many other products invented during the Second World War, including duct tape, which was developed by Johnson & Johnson to keep moisture out of ammunition cases. A fellow called Harry Coover discovered cyanoacrylates – the active ingredient in Super Glue – while he tried to create a clear plastic for gun sights.

And the next time you reheat your dinner, spare a thought for Percy Spencer, the US physicist who noticed the candy bar melting in his pocket when he stood next to an active radar set. This moment of epiphany led to an invention you might know: the humble microwave.

Accelerating penicillin and vaccine rollout

Just as these trying times lead to extraordinary leaps in technology, they also lead to the large-scale rollout of said discoveries. A prime example of this is penicillin. It was first used to treat an eye infection in 1930, but it was only with the horrific fall-out of war that experiments with deep tank fermentation led to its widespread production.

A soldier recuperates in hospital thanks to penicillin in this Second World War poster. Note the not-quite-so-life-saving hospital bed cigarette. Different times, again.

The Penicillin Production through Deep-tank Fermentation paper in ACS notes that: ‘During World War II, the governments of the United States and the UK approached the largest US chemical and pharmaceutical companies to enlist them in the race to mass produce penicillin […] One of these companies, Pfizer, succeeded in producing large quantities of penicillin using deep-tank fermentation.’

The speed of development and global-scale rollout of vaccines against Covid-19 was unprecedented. Science, business and governments worked together to get the world moving again.

And, as we all know, Pfizer was back at it again during the Covid-19 pandemic. Along with AstraZeneca, Moderna, and essentially the entire pharmaceutical industry, it created vaccines that saved countless lives. Governments and policymakers were also reminded just how quickly life-saving technologies can be pushed through when needed.

But the legacy of Covid-19 treatment will stretch further, be it in nanotechnology, artificial intelligence, or other fields – who knows what else will come from it?

As Paul Booth said: ‘It is possible to accelerate innovation. We’ve demonstrated that.’

Many believe that greenhouse gas removal technologies will be necessary if we’re to reach net zero by 2050. In the first of our two-part geoengineering feature, we look at some of the difference-makers.

This week, a friend of mine played a tennis match just north of London. The game was due to take place at 18:00 but was deferred for an hour because it was 39°C. This came a day after Rishi Sunak, who may become the UK’s next Prime Minister, warned about going ‘too hard and too fast’ on net zero measures.

It’s looking increasingly likely that the implementation of environmental policies isn’t happening quickly enough; so, if we want to avoid catastrophic climate change, we will need to develop technologies that pull carbon dioxide from the atmosphere.

Mercury rising: the UK recorded record high temperatures this week.

Certainly, that’s the UK government’s perspective. ‘Greenhouse Gas Removal technology will be essential to meeting the UK’s climate change target of net zero carbon emissions by 2050,’ it said. ‘These technologies will be necessary to offset emissions from hard to decarbonise areas, such as parts of the agriculture and aviation sectors.’

Thankfully, work is underway to make this happen. And it is more than just the pang of the environmental conscience that has stirred the private sector into action. There is much money to be made from geoengineering. Indeed, a CNBC story has estimated that it could be a trillion dollar market by 2050.

The public investment has been relatively modest by some. The UK government recently pledged £54m in funding towards 15 different carbon removal technologies. But some in the private sector have dollar signs in their eyes.

A collaborative called Frontier – funded by Stripe, Alphabet, Shopify, Meta, McKinsey, and tens of thousands of businesses using Stripe Climate – has made an advance market commitment to spend an initial $925m on permanent carbon removal technologies between 2022 and 2030.

‘Models project that by 2050 we will need to permanently remove billions of tons of CO₂ from the atmosphere every year,’ it states. ‘To date, fewer than 10,000 tons have been removed in total.’ The capital it has committed is designed to help companies developing carbon removal solutions to scale up.

The UK government has mentioned the need for a portfolio of carbon removal technologies to reach net zero. A cursory look reveals that there are many from which to choose, including direct air capture, the manipulation of the sea, advanced weathering, and solar engineering.

These methods are audacious, exciting, and controversial.

Direct air capture

The key, as ever, is to come up with low-carbon technologies that are both effective and economically viable. In that respect, direct air capture has emerged as a front runner. This technology often uses giant fans with filters, or chemical processes, to take CO₂ from the air.

The difficulty is the amount of energy needed to power these processes and the source of this energy. The cost of removing each tonne of CO₂ is also an impediment to growth – something that will need to fall for it to be implemented on a large scale.

Climeworks co-founders Jan Wurzbacher and Christoph Gebald at the Orca plant in Iceland. Image courtesy of Climeworks.

Nevertheless, significant strides have been made in recent times. Swiss company Climeworks raised US$650m in equity for its largest direct air capture plant, and last week it inked a 10-year deal with Microsoft to permanently remove 10,000 tonnes of CO₂ emissions from the atmosphere on its behalf.

The company’s machines capture CO₂ from ambient air by drawing air into the collector with a fan. The CO₂ is captured on the surface through a selected filter material that sits inside the collectors. Once the filter is filled with CO₂, the collector is closed, and the temperature is increased to 80–100°C, whereupon the CO₂ is released.

And what becomes of the CO₂ after that? The CO₂ at its Orca facility (50km outside Reykjavík, Iceland) will be mixed with water and pumped deep underground. The carbon dioxide will then react with the basalt rock through natural mineralisation and turn into stone.

Climeworks CO₂ turned into stone via Carbfix technology. Image courtesy of Climeworks.

And Climeworks isn’t the only one operating in this space. As part of the UK Government’s aforementioned £54m funding, London-based Mission Zero Technologies will receive £2.9 million to build a low-energy, heat-free way to pull CO₂ from the air.

Sydney-based AspiraDAC has been backed by the Stripe Climate Fund to remove 500 tonnes of CO₂ using its modular, solar-powered system. According to Frontier: ‘Its MOF (metal-organic framework) sorbent has low-temperature heat requirements and cheap material inputs, increasing the likelihood that AspiraDAC can help accelerate the production of lower-cost metal-organic frameworks which, historically, have been expensive and difficult to synthesise.’

The Stripe Climate Fund has also backed 8 Rivers Capital, LLC, and Origen Carbon Solutions, Inc to remove CO₂ from the air using its direct air capture (DAC) technology. Frontier said: ‘The DAC technology accelerates the natural process of carbon mineralisation by contacting highly reactive slaked lime with ambient air to capture CO₂. The resulting carbonate minerals are calcined to create a concentrated CO₂ stream for geologic storage.’

Of course, direct air capture is just one of many CO₂ removal solutions. In part two, next week, we’ll look at other promising technologies.

In his winning essay in SCI Scotland’s Postgraduate Researcher competition, Angus McLuskie, Postgraduate Researcher at the University of St Andrews, explains his work in replacing non-renewable and toxic feedstocks with novel sustainable catalytic processes to produce useful chemicals.

Each year, SCI’s Scotland Regional Group runs the Scotland Postgraduate Researcher Competition to celebrate the work of research students working in scientific research in Scottish universities.

This year, four students produced outstanding essays in which they describe their research projects and the need for them. In the first of this year’s winning essays, Angus McLuskie outlines his work in improving the production of urea derivatives and polyureas.

Would you risk your life for plastics and agrochemicals? You might not have to…

Urea derivatives hold a substantial global market, which is dominated by their use as fertilisers in the agrochemical sector, in addition to smaller-scale technical applications as glues, resin precursors, dyes and pharmaceutical drugs. Furthermore, polyureas are important protective coatings, with a global market exceeding £800 million a year.

Currently, urea derivatives and polyureas are produced on an industrial scale using highly toxic chemicals such as phosgene, (di)isocyanates and carbon monoxide. These reagents are detrimental to human health, as evidenced by the release of methyl isocyanate gas from the Bhopal Union Carbide factory in 1984, which led to thousands of deaths and a global outcry.

Phosgene was itself used as a battlefield chemical weapon in World War I, and is sourced from fossil-fuel-derived carbon monoxide. The result is a process with significant health and environmental impacts.

As part of a global drive to tackle climate change and move towards a circular economy, the objective of our research is to replace non-renewable and toxic feedstocks with novel sustainable catalytic processes to produce useful chemicals and materials.

>> More information about the Scottish Postgraduate Researcher competition.

In pursuit of greener methods, we have recently discovered synthetic methodologies, using a catalyst of manganese, to couple dehydrogenatively (1) methanol and (di)amines and (2) formamides and amines to make symmetrical (poly)ureas and unsymmetrical urea derivatives respectively (ACS Catal., DOI:10.1021/acscatal.2c00850).

Angus with his poster on Mn-Catalysed Dehydrogenative Synthesis of Urea Derivatives and Polyureas.

The only process byproduct, molecular hydrogen, is valuable in itself, and the non-toxic reagents of methanol or formamide can be sourced from renewable feedstocks. For example, Carbon Recycling International, an Iceland-based company, has developed methods to generate methanol industrially through the direct hydrogenation of CO2 (ATZextra Worldw., DOI:10.1007/S40111-015-0517-0). Formamides can be made from formic acid, which may be produced from biomass or CO2.

Synthesis approach

The synthesis of urea derivatives using this approach has been reported previously using iron and ruthenium catalysts, but these present individual limitations. Iron catalysts result in poor yields and substrate scope, while ruthenium catalysts are expensive and raise sustainability concerns due to ruthenium’s low abundance in Earth’s crust (Chem. Sci. J., doi.org/10.1039/C8SC00775F and Org. Lett., doi.org/10.1021/acs.orglett.5b03328).

The synthesis of polyureas via this approach has only been achieved before using a ruthenium catalyst. With a manganese-based pincer catalyst, we succeeded in making a broad variety of symmetrical and unsymmetrical urea derivatives as well as polyureas at high yields and under a low catalytic loading of 0.5-1 mol%. As the third most abundant transition metal in Earth’s crust, manganese is much cheaper than ruthenium, which improves the economic viability of the process for industrial applications.

Breaking new ground?

This is the first example of the synthesis of polyureas from diamines and methanol using a catalyst of an Earth-abundant metal. We have demonstrated for the first time the synthesis of a potentially 100% renewable polyurea from methanol and a renewable diamine Priamine, which is commercialised by Croda. This could be of interest to emerging businesses for making bio/renewable plastics.

Angus hopes his research will help us develop urea-functionalised agrochemicals and pharmaceutical drugs in a more efficient, greener way.

This initial proof of concept is exciting, but there are challenges to overcome for commercialisation. Evidently, the cost is important, and since the catalyst is much more expensive than reactants, such as amines and methanol, the cost is directly linked to the catalyst’s activity; a homogeneous catalyst that is non-recyclable and offers a turnover number of 100-200 makes the process expensive.

We are now focusing our efforts on enhancing the efficiency of the catalyst to increase cost-effectiveness, which will also allow us to make commercially important urea-functionalised pharmaceutical drugs and agrochemicals with greater efficiency and reduced impact on the environment, human health, and economy.

>> Interested in joining the SCI Scotland Group?

What is the verdict on the 100% sustainable fuel Formula 1 plans to use in its cars, and is the new E10 fuel this season doing any good? We asked David Bott, SCI’s Head of Innovation.

Beware of Greeks bearing gifts. This phrase comes from Virgil’s Aeneid, and it refers to the Greeks’ gift of a giant wooden horse to their enemies during the Trojan War. But this was no gift at all.

This warrior-filled, hollow wooden horse that the Trojans wheeled inside the gates of Troy was a ploy from the Greeks to get inside the city’s impenetrable city walls and ambush their enemy. It turned out things weren’t quite what they seemed.

Just as Trojans became wary of giant wooden horses, we should be wary of Net-Zero pledges. These promises seem impressive but, if you look inside, they might not be quite as beneficial to the environment as advertised – at worst, they could be hollow.

Whenever an organisation talks of carbon credits, makes a vague reference to biomass or a grand pledge with little detail, it is worth closer investigation.

Formula 1 recently made a sustainability pledge of its own. Following its decision to use E10 fuel in the cars this season (a mixture of 90% fossil fuel and 10% ethanol), it has announced plans to use a 100% sustainable drop-in fuel in its vehicles as part of its plans to reach Net-Zero by 2030.

On first reading, the terms Net-Zero and Formula 1 don’t sit easily together. Isn’t this the sport where 20 cars can burn more than 100kg of fuel each per race? The same travelling circus in which cars, teams, and drivers are flown and ferried all over the world for more than eight months of racing?

By its own calculation, in a November 2019 report, Formula 1 is responsible for 256,551 tonnes of carbon dioxide emissions each year. To put that figure into perspective, you would need to drive for 6,000km in a diesel car to generate a single tonne of carbon emissions – multiply that by 256,000, and Net-Zero feels some distance away.

What about the E10 and proposed drop-in fuels?

Both Formula 1’s new fuel and pledges merit closer inspection. Regarding the move to the E10 fuel in Formula 1 cars, David Bott, SCI’s Head of Innovation, wasn’t exactly gushing.

‘E10 is an evolutionary backwater – adding just 10% ethanol does nothing for emissions,’ he said. ‘A quick enthalpy calculation shows the energy in the fuel has decreased, so you need more.’

The proposed move to a ‘100% sustainable drop-in fuel’ used in standard internal combustion engines is seen by many as a positive move. Formula 1 says the fuel will be made using components from either carbon capture, municipal waste, or non-food biomass.

Each of these ‘components’ on its own is worth exploration. For example, what types of municipal waste do they mean, which types of non-food biomass are they talking about, and what about the manufacturing process?

Biomass fuel is controversial due to concerns over carbon sequestration and land use.

The passage of time will reveal more but, again, David has questioned the green credentials of the proposed fuel. He said: ‘What Formula 1 is proposing to do is analogous to sustainable aviation fuel – to make octane from a non-fossil source of carbon.’

‘[To do this], you can use biomass or “synthetic”, which basically means distillate plastic waste. It is effectively using fossil carbon that was used for something else; so, it doesn't make the situation any worse, but neither does it really contribute to lowering emissions. It’s just short-cycle carbon.’

Freight with difficulty

The mention of aviation is pertinent when it comes to Formula 1. The emissions generated by the 10 teams’ vehicles across 21 Grands Prix, including races and testing, account for just 0.7% of Formula 1’s total emissions. But by far the biggest contributor to its CO2 emissions are logistics – the movement of equipment from venue to venue by land, sea, and air.

The equipment used in Formula One must be transported from continent to continent by sea, land, or air.

After that comes business travel at 27.7%, which includes the air and ground transportation of all individuals, as well as the hotel footprint from all Formula 1 teams’ employees and major event staff. So, it’s clear that the main environmental problem isn’t the fuel used during the races; it is all of the other transport emissions.

To be fair to Formula 1, the sport has made an effort to make operations greener, including powering its offices using 100% renewable energy and taking measures to make freight more efficient.

However, any claims that it is motoring to Net-Zero by 2030 need to be chased with a liberal swig of scepticism. A Net-Zero 2030 goal provides a nice headline, but how you get there is the story.

Is it dipping your finger into a glistening bowl of mercury? Is it symmetry? Is it the patterns of crystal growth or is it to be found in nature – in the neatness of evolution? In his thought-provoking SCItalk, Philip Ball explored the beauty of chemistry.

When you write fiction, you’re supposed to wake all the senses. So, don’t just tell readers what something looks like. Tell them how it feels. Tell them how it sounds. Tell them how it tastes. For beauty exists in the smell of perfume as someone walks by, just as it resides in the colours of bloom. One of the beauties of chemistry – like nice writing – is that it also evokes all of the senses.

That was what drew Philip Ball to chemistry: the profusions of colour, the explosions, the reek of sulphur, dipping his finger into a bowl of mercury as a lad and wondering how this dense, silvery liquid hadn’t made his hand wet.

And yet, chemists – and scientists in general – seem to have a complicated relationship with beauty. Part of this is down to what different groups see as beautiful. ‘When scientists talk about beauty,’ he said, ‘they think they’re talking about what artists are, but they really aren’t.’

A chemical garden formed from copper nitrate in sodium silicate solution by Yan Liang and Wenting Zhu.

For a physicist, an equation might capture the essence of beauty. For a chemist, it might be the shape of a crystal growth formation. Ball argued that chemists tend to be Platonists – that they locate beauty in symmetry (for Plato, he added, art was too messy ever to be beautiful).

Chemistry’s reputation as a staid science isn’t helped by the fact that it has long hidden its light from the world. Much beauty is confined to those who view it under microscopes. It is only relatively recently – with the proliferation of high-resolution imagery – that the public has finally looked upon the beauty of chemical gardens, processes, and configurations in all their stunning detail.

Even so, despite the bewitching quality of seeing copper hydroxide billowing like a jellyfish, and the jagged architecture of lead formations, much of chemistry’s beauty lies in its dynamism, rather than the confines of the still frame.

The inspiration of nature

And yet, it wasn’t ever thus. Chemistry in bygone centuries was viewed slightly differently. ‘Of the chemistry of his day and generation, [the German philosopher] Kant declared it was a science, but not Science,’ Ball noted.

Similarly, in Frankenstein, Mary Shelley painted chemistry in a different light to how it is seen today. ‘Chemistry is that branch of natural philosophy in which the greatest improvements have been and may be made,’ her character, Professor Waldman, said.

The sheer beauty in science has long been appreciated, as is seen in this cyanotype photogram made by Anna Atkins in her 1843 book, Photographs of British Algae: Cyanotype Impressions.

So, why the small s? Why was it seen, not as a soft science, but one with a softer underbelly – like a stone-faced steel worker who secretly writes poetry? Perhaps it has to do with the link to creation. ‘Chemists display, arguably, the greatest creativity in the sciences,’ Ball said. ‘[They have] the urge to make stuff.’

This creativity is often guided by the beauty of the natural world. Ball argues that some scientists are guided by the sheer beauty of nature, by finding the unexpected in things we have seen so many times before.

On the screen, he put up a picture of what looked like the intricate component of a motor, which turned out to be the natural motor structure within bacteria driving its very survival. He mentioned the pigments within flower petals, so delicately tuned by evolution.

An extraordinary bacteria motor (left). Image from paper on: Structural basis of assembly and torque transmission of the bacterial flagellar motor. Created by Zhejiang University researchers..

Simply put, the elegant solutions found by nature are inspiring. ‘It made me think about what Einstein said,’ he added. ‘The Theory of Relativity was so beautiful to him that he believed nature had to work this way.’

And some chemists are drawn by a different type of aesthetic: the beauty of the method. Just as a football fan might rhapsodise about the arc of a perfectly struck free-kick as it curves beyond the keeper’s reach, some chemists see something in the process. ‘For some chemists, there’s a beauty in the synthesis,’ Ball said; and other chemists, he added, will have their own aesthetic responses to an approach, be it elegant or otherwise.

Why shouldn’t the work of a chemist be driven, in part, by beauty? And why should the arbiters of the aesthetically pleasing be confided to the arts? For Philip Ball, the chemical world is one of artistry, dynamism, and beauty. For him, science provides a new lens, new tools for seeing, and new ways for looking at the world around us.

‘Science doesn’t de-enchant the world,’ he said. ‘On the contrary, it re-enchants it.’

Philip’s book, The Beauty of Chemistry, is published by MIT Press.

What makes chilli peppers so spicy and how do they help with pain relief? The SCI Horticulture Group explained all ahead of their appearance at BBC Gardeners’ World Live in Birmingham from 16-19 June.

This June, the SCI Horticulture Group will tell the public all about the hidden chemistry behind their favourite fruit and vegetable plants. One of the main plants they will feature at the National Exhibition Centre is the humble chilli pepper – and these famous fruit-berries conceal more secrets than you might think…

Where does the chilli originate?

The chilli pepper (Capsicum spp.) is a member of the Solanaceae, the plant family that includes edibles such as potatoes, tomatoes, aubergines, but also poisonous plants such as tobacco, mandrake, and deadly nightshade.

Who brought the chilli pepper to these shores?

The chilli was brought to Europe in the 15^th century by Christopher Columbus and his crew. They became acquainted with it on their travels in South and Central America and, shortly thereafter, to India via the Portuguese spice trade.

How varied is the genus?

Of the 42 species in the capsicum genus, five have been domesticated for culinary use. Capsicum annuum includes many common varieties such as bell (sweet) peppers, cayenne and jalapenos. Capsicum frutescens includes tabasco. Capsicum chinense includes the hottest peppers such as Scotch bonnet. Capsicum pubescens includes the South American rocoto peppers, and capsicum baccatum includes the South American aji peppers.

From the five domesticated species, humans have bred more than 3,000 different cultivars with much variation in colour and taste. The chilli and bell peppers that we eat are the fruit – technically berries – that result from self-pollination of the flowers.

>> The SCI Horticulture Group brings together those working on the wonderful world of plants.

And we eat a lot of them?

Today, chilli peppers are a global commodity. In 2019, 38 million tonnes of green chilli peppers were produced worldwide, with China producing half of the total. Spain is the largest commercial grower of chillies in Europe.

Capsaicin helps give chilli peppers their heat

What makes chillies hot?

Capsaicin is the main substance in chilli peppers that provides the spicy heat. It binds to receptors that detect and regulate heat (as well as being involved in the transmission and modulation of pain), hence the burning sensation that it causes in the mouth.

In humans, these receptors are present in the gut as well as the mouth (in fact, throughout the peripheral and central nervous systems) – hence the after-effects of eating too much chilli. Capsaicin, however, is not equally distributed in all parts of pepper fruit. Its concentration is higher in the area surrounding the seeds.

>> Get tickets for Gardeners’ World Live 2022 and pop by our stand to say hello!

How do you measure chilli heat?

The Scoville Heat Unit Scale is used to classify the strength of chilli peppers. Scoville heat units (SHU) were named after American pharmacist Wilbur Scoville who devised a method for rating chilli heat in 1912.

The ludicrously hot Dragon’s Breath chilli

This method relied on a panel of tasters who diluted chilli extract with increasing amounts of sugar syrup until the heat became undetectable. The greater the dilution to render the sample’s heat undetectable, the higher the SHU rating. Pure capsaicin measures 16,000,000 SHU.

The capsaicin content of chilli peppers varies wildly, as is reflected in the SHUs of the peppers below:

1. Bell (Sweet peppers) = 0 SHU
2. Jalapeno = 5,000 SHU
3. Scotch Bonnet = 100,000 SHU
4. Naga Jolokia = 1,040,000 SHU
5. Carolina Reaper = 1,641,183 SHU
6. Dragon’s Breath = 2,480,000 SHU

Dispersal vs. protection – why do chillies contain capsaicin?

The seeds of chillies are dispersed in the wild by birds who do not have the same receptors as mammals and, therefore, are unaffected by capsaicin. Perhaps chillies have evolved to prevent mammals from dispersing their seeds?

Capsaicin has also been shown to protect the plant against fungal attack, thus helping the fruit to reach maturity and the seeds to be dispersed before succumbing to rot. This antifungal property can also be put to good use in helping to preserve foods for human consumption.

How did chilli help win a Nobel Prize?

Capsaicin was pivotal in the research that led to the award of the 2021 Nobel Prize in physiology and medicine to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch.

The two US-based scientists received the accolade for describing the mechanics of how humans perceive hot, cold, touch, and pressure through nerve impulses. The research explained at a molecular level how these stimuli are converted into nerve signals, but the starting point for the study was work with capsaicin from the humble chilli pepper.

Capsaicin in medicine

Capsaicin is used as an analgesic (a pain reliever) in topical ointments, nasal sprays, and patches to relieve chronic and neuropathic pain. Clinical trials continue to investigate the potential of capsaicin for a wide range of additional pain indications and as both an anti-cancer and anti-infective agent.

>> Special thanks to Neal Price from Chillibobs, Martin Peacock of ZimmerPeacock, Hydroveg, and The University of Reading Soft Fruit Technology Group for supporting the work of the SCI Horticulture Committee at BBC Gardeners’ World Live.

>> Our resident gardening expert, Geoff Dixon, provides plenty of gardening tips on the SCIBlog.

Have you ever seen a snowflake up close? Have you smelt fertiliser on a country drive? Chemistry is the most sensuous of the sciences, and it may just be the most beautiful too. In our latest SCITalk, Dr Philip Ball showcases the breathtaking beauty of chemistry.

Main image: A chemical garden formed from copper nitrate in sodium silicate solution by Yan Liang and Wenting Zhu.

Even the most disciplined of us falls into these rogue states from time to time, minutes of total absorption unrelated to work or duty. For some, it is the humble cat video. For others, it is the endless tapestry of Twitter.

Crystals of nicotinic acid by Yan Liang and Wenting Zhu.

For me, this morning, it was a time-lapse video of crystal growth patterns. The world temporarily stopped moving as I fell headlong into high-resolution pictures of icy fronds appearing and clusters of spikes combining to form crystalline towers. Who knew potassium nitrate, ammonium chloride, and monopotassium phosphate could be so beautiful?

It turns out, Dr Philip Ball did. He knows all about the beauty of chemistry – from its profusions of colour to the hypnotic beauty of snowflakes forming.

Oxygen bubble from decomposing hydrogen peroxide by Yan Liang and Wenting Zhu.

Dr Ball argues that chemistry is the most sensuous of the sciences. Which of us hasn’t smelt the stink of sulphur or the sting of ammonia in our nostrils? When he unveils vivid, other-worldly pictures of chemical gardens, or even when we see a close-up of water being added to a bowl of M&Ms, it’s hard to disagree with his view.

This Wednesday evening, 25 May 2022, Dr Ball will deliver his SCI Talk about the beauty of chemistry and his book of the same name, which he put together with photographers Yan Liang and Wenting Zhu. Using microphotography, time-lapse photography, and infrared thermal imaging, they have captured astonishing photos of chemical processes.

They have captured a beauty seldom seen, except by chemistry’s day-to-day practitioners. They show us the chemistry of champagne in a new light and the transformations of evaporation and distillation. They unveil the strange world of chemical gardens – from the blue tendrils of copper nitrate in sodium silicate solution, to the silky precipitation of silver chromate.

Precipitation of silver chromate by Yan Liang and Wenting Zhu.

Some defend the beauty of science by conflating it with the pursuit of truth. As the famous snippet from Keats’ Ode on a Grecian Urn goes: ‘Beauty is truth, truth beauty.’ Yet, it’s clear that the beauty of chemistry does not need to be defended in such abstract terms. It’s there in champagne bubbles and the deft configurations of a snowflake. You just need to look into a microscope - or plunge mind-first down a YouTube rabbit hole.

Register here to watch the Beauty of Chemistry SCItalk this Wednesday 25 May 2022.