The 42nd SCI Process Development Symposium on 15-17 April 2026 brings together speakers from the Pharmaceutical, Agrochemical and Fine Chemical industries, as well as academics in these areas, to present innovations in the scale up of new synthetic processes.

Ahead of the event we asked speakers Dr Michael Luescher, Process R&D Chemist at Novartis and Dr David Thaisrivongs, Director of Process Research and Development at MSD a couple of questions on the state of process development and chemistry in general.

MC: Where do you think the biggest challenges are in your field in the next 20 years?

DT: ‘The complexity and diversity of molecules being discovered and commercialized in the biopharmaceutical industry continues to increase, and each one brings new and complex process development problems to solve. What was once a field largely comprised of small organic molecules, antibodies, and vaccines is now one filled with new modalities, including synthetic peptides, antibody-drug conjugates, protein degraders, nucleic acids, and cell and gene therapies. These new frontiers present novel challenges to inspire process development scientists to invent and develop new methods for their production to enable broad access to these molecules to improve and extend the lives of patients worldwide.’

MC: Where do you see the most exciting advances being made in the next 20 years in your field?

DT: ‘Developments in biocatalysis over the last 20 years are now leading a revolution in chemistry. What was once an experimental idea has become an essential synthetic technology to enable manufacturing processes that significantly improve the efficiency and sustainability of more traditional chemical methods. Yet despite extraordinary advances in the application of enzymatic catalysis to solve problems in chemistry, especially the simultaneous use of multiple biocatalysts to perform different synthetic functions as Nature does, we as a field have only scratched the surface of the kinds of molecules whose manufacture will be enabled by biocatalysis.’

MC: What one piece of advice would you have for a new PhD/postdoc/PI starting today? 

ML: ‘Stay curious, keep an open mind, and don’t limit your focus to your own specialty. Science doesn’t live in a single discipline—it's woven into society and the broader world around us. Meaningful breakthroughs often emerge when diverse ideas and perspectives come together. Collaboration and inclusion aren’t just ideals; they’re powerful drivers of innovation, something I had the privilege to experience firsthand at Novartis.’

How we can face these challenges, embrace the opportunities, and work across disciplines to drive innovation in process development will be discussed in much more detail at the symposium.

Read the full event programme

How we cracked the code for hunger

A world where hunger can be dialled down, with medications that alter the desire for food, sounds like something from a science fiction novel. However, GLP-1 therapies, which mimic or enhance the action of the hormone GLP-1, are very much real, and their prominence and effectiveness raises significant questions for society. Is this a medical marvel, a social experiment, or an evolutionary step forward?

What are GLP-1 therapies?

GLP-1 therapies tap into the body’s own biology to regulate hunger, blood sugar, and energy use. The GLP-1 hormone coordinates how the brain, pancreas, stomach, and broader metabolism respond to food – it is one of the signals that makes you feel that you have had enough to eat. These therapies reduce appetite and cravings by acting on the brain, make the stomach empty food more slowly, and improve glucose regulation by stimulating insulin release and suppressing glucagon.

Earlier weight-loss drugs worked by increasing metabolism, suppressing appetite crudely, or affecting mood and alertness. Many came with serious side effects. The physiology of GLP-1 therapies is well understood, and have enabled consistent, sustained weight loss in clinical trials. These results, as well as celebrity use and popular trends, have brought these therapies into the forefront of public consciousness.

Rewiring appetite, behaviour, and identity

These isn’t just about obesity. These drugs alter appetite, impulses, and our relationships with food. They challenge how we think about motivation, and responsibility.

Furthermore, there are broader social and ethical questions. Who stands to benefit from these therapies? What does this mean for children, adolescents, or older adults? What is the role of social media networks in influencing the up-take of these therapies?

Learn more

Accomplished endocrinologist Dr Emran Ghaffar Khan will explore this intriguing topic in his upcoming SCI talk, “Hacking the brain’s hunger code: Miracle, menace, or the next stage of human evolution?”. You can join the conversation and sign up for the talk here: Hacking the brain’s hunger code: Miracle, menace, or the next stage of human evolution?

Six teams have made it to the exciting final of this year’s Bright SCIdea Challenge.

The Bright SCIdea Challenge sees university students develop an innovative science-based idea into a business plan - and then to compete for a £5,000 prize.

SCI supports entrants during the competition by delivering free, exclusive training, and the teams with the strongest business plan are invited to deliver their pitch to an expert panel of experienced, successful senior business people and innovators.

The first Bright SCIdea challenge took place in March 2018 and since then the competition has seen winners go on to launch companies, raise significant funding and take their products to market.

This year’s final - the seventh instalment of SCI’s annual entrepreneurship competition - takes place at SCI’s headquarters on March 17.

Here are the 2026 Bright SCIdea Challenge finalists:

Ascenx

Sophie Siu, William Wang, Justin Wong and Gwen Rico

Where are they from?
University College London

Why did they enter the Bright SCIdea Challenge 2026?
“As second year chemistry students we were keen to apply our theoretical knowledge to a viable business idea under the guidance of industry experts in a fun and dynamic setting. Our entry was catalysed by reading a paper by Kaifeng Wang and Case M. van Genuchten which discussed a novel process of retrieving arsenic from wastewater sludge. We were fascinated by the chemistry and its dual potential of ensuring clean drinking water whilst supplying a sustainable arsenic source. The opportunity to contribute to a meaningful global impact strongly aligned with our humanitarian values and motivated us to participate.”

AvennaX

Josh Das, Peilin Chen and Tara Hudson-Ballard

Where are they from?
Imperial College London

Why did they enter the Bright SCIdea Challenge 2026?
“We entered the BrightSCIdea challenge to accelerate the commercial scaling of AlphaSuite, build a network of other scientific innovators, and gain mentorship from experts. This competiton offers the opportunity to develop our roadmap for market entry, ensuring our innovation is positioned for long term growth. Winning would provide the foundational funding for us to scale our technical infrastructure and secure our IP, and the insights gained from this experience will help us turn our innovation into a successful venture truly valuable to the global research and healthcare community.”

CheGo

Cheyenne Gracias, Chayanit Panjak, Hita Dunukunala and Yunseo Lee

Where are they from?
Kings College London

Why did they enter the Bright SCIdea Challenge 2026?
“Having previously won a hackathon, our team believes real impact comes from bringing solutions to industry which is why BrightSCIdea felt like the right next step. Our inspiration came from a teammate's mother, an experienced ICU nurse, who described how suctioning can cause bleeding and stress for patients and nurses. This sparked our add-on sensor system that transforms standard closed suction catheters into precision-guided medical devices, reducing complications in intensive care. Beyond technical skills, we recognised the need for commercialisation expertise. This competition offers industry feedback, workshops, and funding to develop our prototype into a real product.”

MediKeto

Nano Kojima, Yuri Fujikura and Eleina Hames

Where are they from?
Institute of Science Tokyo

Why did they enter the Bright SCIdea Challenge 2026?
“The ketogenic diet is a highly evidence-based treatment for drug-resistant epilepsy, yet it remains underutilised because of the daily management burden. We built MediKeto to change that.

"As an early-stage team bridging medicine and engineering, the Bright SCIdea Challenge offers something distinct: international validation, critical feedback and support from industry experts, and funding that would directly accelerate our pathway from healthcare app to SaMD. We are determined to refine our concept and empower patients and families who need it most, ultimately boosting treatment adherence and unlocking a better quality of life.”

Napré

Nwachukwu Christiana Okonkwo, Kosisochukwu Judith Offojebe, Ikwuezuma Elochukwu Reynolds and Ekeomodi Chikodi Christabel

Where are they from?
Newcastle University, McGill University, Nnamdi Azikiwe University and Stellenbosch University

Why did they enter the Bright SCIdea Challenge 2026?
“Our participation in Bright SCIdea challenge was driven by our identification of a critical gap in the manufacturing industry: while billions are spent producing drug and food products, the adverse effects of the preservatives used in these products have been largely neglected. We saw an opportunity to change the status quo and create a paradigm shift to safer preservatives while protecting the environment - through the valorisation of agricultural waste. Bright SCIdea offers us an opportunity to connect with visionary partners who share our goal: to disrupt a dysfunctional market with innovative solutions that promote well-being without sacrificing commercial value.”

QROOT — Quantum Reactive Optical Observation of Terrain

Gergo Meszaros, Hassan Raza Khan and Kaden Ethan Tan

Where are they from?
University of Toronto and Brown University

Why did they enter the Bright SCIdea Challenge 2026?
“Uncertainty. Corporations cannot always predict crop yields or the best interventions. Farmers cannot know whether fields will suffer from disease or deplete prior to the first harvest—yet they plant, nurture, and persevere anyway. If they can act despite uncertainty, why shouldn't we? The practicality of scaling a business, of turning innovation into impact, and reaching those who need it most was unknown to us—but because they try, we must too. With BrightSCIdea we have our expertise, the guidance of industry experts, and the network to bring QROOT to life, that is why we are here.”

As an organisation that is proud of its members, SCI is always looking for ways to better serve its community of innovators. That’s why our Director of Stakeholder Engagement, Kirstie Cochrane, and Senior Stakeholder Engagement Manager, Bryony Parker, stepped away from their desks for the day and attended the Memberwise Annual Conference, Membership Excellence.

Membership Excellence is the largest membership focused national conference for the association and membership sector in the UK, which is focused on planning for the future and driving membership growth. As the largest membership-focused event in the country, it is a one-day experience for membership professionals seeking to learn, innovate and excel in membership strategy, engagement, growth and retention.

It's an interesting environment for the stakeholder engagement team to experience as we can learn from other organisations that offer membership to individuals and institutions. The conference was held in London and had over 600 delegates all with a passion for delivering excellence in membership. There were some great Keynote sessions from organisations as varied as the Institution of Engineering and Technology (IET), Institution of Chemical Engineers (IChemE), Royal Horticultural Society (RHS), Parkinsons UK and the National Trust.

What the experts shared

Among a variety of talks was ‘Mentoring in Practice: For both Personal Growth and Member Value’. SCI’s Mentoring Programme has been running for several years, and while this is a popular benefit for both mentees and mentors, this session was really helpful in identifying ways to grow interest and participation from mentors, particularly encouraging women and those from minority backgrounds to take part.

With a fantastic breadth and depth of organisations in attendance it was insightful to hear from the IET about their membership journey, and how they have recently developed a centre of excellence approach which aims to put member engagement as the priority across the entire organisation. This has seen the IET take a member-first approach to sales, customer service, transparency on pricing and process improvements.  

Another highlight was hearing from the RHS about their rebranding and broadening its membership appeal, and how they have used digital innovation and data insight to enhance personalisation, improve member experience, and drive engagement. This has given us a lot to think about from the membership team, on how we provide our membership services and the tools and toolkit that we can use to support our wonderful members. 

So far in 2025, SCI has welcomed more than 830 new members to its vibrant community of scientists, innovators, students and professionals. They contribute to our exceptional programme of events, support the running of our technical and regional groups, showcase how science meets business and recognise each other for scientific awards - it really is one of the most inclusive and supportive organisations.

We are a small team here at SCI supporting membership and we are always looking for ways to facilitate members on their journey through from studying at university, to their first role in a science-based business and beyond with a flourishing career.  We offer support for students to engage with potential employers, cross industry mentoring programme, access to technical content for scientists and a corporate partner network that embodies where science meets business.

Get in touch to find out more about being an SCI member!

BY DAVID BOTT

There is an old saying that “no strategy survives first contact with the enemy” (though I prefer Mike Tyson’s more descriptive version “everyone has a plan until they get punched in the mouth”!).  When we were planning the Flue2Chem project, we drew out a detailed Gantt chart with deliverables, dependencies and deadlines.  Sadly, the elapsed time between the last post in this series and now is a vivid example that Mike Tyson got it right.

To recap, the aim of the Flue2Chem project is to collect the carbon dioxide from flue gases and turn it into a simple non-ionic surfactant for use in detergents and other consumer goods – potentially eliminating the need to extract more fossil fuel to make them. Key intermediates are dodecanol and ethylene oxide, but the first step is to capture the carbon dioxide.

What has gone before

The idea of extracting carbon dioxide from flue gases has been around for a long time, and has actually been “practiced” since the 1950’s.  For a long time, it has been driven by the idea that carbon dioxide emissions can be captured and stored underground, thus avoiding adding them to the atmosphere and causing climate change.  Nowadays, if you go to a Carbon Capture Utilisation and Storage (CCUS) conference, the few talks on utilisation mostly talk about the direct use of carbon dioxide either in fizzy drinks or for pumping into greenhouses as a feed to horticulture.  We are aiming for something different.

The first need is for a source of flue gases.  When we were putting together the Flue2Chem consortium we understood that different sources would have different chemical compositions, so we sought out different types of sources to maximise the spread of data for both the techno-economic and life cycle analyses.  There are two paper companies in the consortium, Holmen and UPM.  Their carbon dioxide emissions are classified as “biogenic”.  Both have biomass combined heat and power plants, built in the days when biomass was regarded by the government as a renewable power source, and subsidised under the renewable obligations scheme that formed part of the 2009 Renewable Energy Directive.  They each generate about 1000-1500 tonnes of carbon dioxide a day.

We also had the Port Talbot site of Tata Steel as part of the project.  You could classify the carbon here as “used fossil carbon”.  Coal is used both as a source of heat and as a reducing agent to turn the iron ore into iron.  It is a complex process and so there are many sources of carbon dioxide on the Port Talbot site, some mixed with carbon monoxide   In total, they generate about 15000-20000 tonnes of carbon dioxide a day.

The basic requirement for a process to capture carbon dioxide is easy to state – you need a system that will reversibly absorb carbon dioxide, and some good engineering!

The liquid amine route for capturing carbon dioxide uses a mixture of amines to react with the carbon dioxide to form carbonates.  The absorption is usually carried out in a vertical column where the amine trickles down in a packed column and the carbon dioxide flows up.  The resulting carbonate is then moved into another column where it is heated to decompose the carbonate to reform the amine and release the carbon dioxide.  The energy efficiency of the process is largely determined by the energy required to decompose the carbonate.  Over the years, different companies have optimised their mixture to minimise the energy costs and often keep this as “black art”.

Solid state absorption systems rely on physisorption.  They used to be based on zeolites, but many recent ones use metal-organic frameworks.  The early ones used a similar temperature driven process to control the absorption and desorption, but there are now systems based on pressure swing, where the absorption is driven by higher pressure and the desorption by much lower pressures.  These are suggested to use lower energy than the more conventional temperature driven systems.

So, how is it going?

Early on in the project, one of the two companies providing the capture systems we wanted to include in the project – Carbon Clean – ran into an issue with the Environment Agency’s policy regarding solvent disclosure. They use an amine based solvent and, as mentioned above, they want to protect the confidentiality of their IP from this major commercial risk. However, the Environment Agency requires disclosure of any chemicals that might be emitted in any process, and most amines have a measurable partial pressure at the temperature used in the carbon capture process, so although they might have been able to get an exemption for a research or test use, once they go commercial in the UK with their system, they will have to disclose to the Environment Agency. AND, the Environment Agency is subject to Freedom of Information requests and would have to disclose Carbon Clean’s proprietary information. This is why Carbon Clean chose to withdraw its technology from the project, while continuing to provide techno-economic analysis.

This led to another decision – this time by Tata Steel.  They had already worked with Carbon Clean in India and were looking to scale up the technology to the 10 tonnes/day envisaged within the project.  With that off the table, they wanted to rethink their plans.  As they were doing so, the bigger announcement that they would close the blast furnaces and move to use electric arc furnaces at Port Talbot amplified their concerns.  Depending on the exact implementation route they choose, there might be minimal emission of carbon dioxide, so they withdrew from the work package to collect carbon dioxide.

Fortunately, in addition to Carbon Clean, we had also included a solid state capture technology, albeit at a much lower state of technology development, in the project.  FluRefin had been developed at the University of Sheffield and was being commercialised by Carbon Capture and Utilisation International (CCUI).  This had been operated at the small scale but as part of the project, it was being scaled up to 1 tonne/day capture.  This required wholly new equipment, some of which had to be imported from India, some from Germany, but was assembled in the UK.  It was planned to be installed at the first collection site (Holmen) at the end of November 2023, was actually delivered to site in mid-January, but commissioning issues delayed the first real carbon capture until late April.  We have learnt a lot about fast-tracking process development – and the challenges it causes, partners working off different versions of the Process and Instrumentation Diagrams, the design experts being in Sheffield and the equipment being in Workington and so on but, as anyone who has done this before will tell you, this is all quite normal and we were very optimistic in our initial plans!  Once on site in Workington, we had the support of some excellent engineers and the various problems were overcome.

One aspect of using a pressure swing process is the need to compress the input gas.  This required the use of a number of compressors, but when they arrived we discovered that they had been designed for compressing air to be used as “compressed air” and were a bit “leaky” on the input side.  We knew this because the output carbon dioxide concentration was lower that the input and not as we needed and thought we would get.  This required more engineering to adapt the compressors for our use.

Another requirement of using the pressure based system is that the input flue gases need to be cooled (from about 150oC to around 30oC) – this recovers a fair amount of heat.  More engineering was required!

Over the next few months, we started to capture enough carbon dioxide to supply the chemical conversion work packages.  But this led to another “challenge”.  We are aiming to capture about 1 tonne per day.  This is below the level where we could engage one of the major gas product companies to provide bottling technology, and we were initially not planning to liquefy the gas (so did not have the required equipment).  This means we were using a fairly basic “put gas in a pressurised gas bottle” process.  Luckily, the University of Sheffield team were also involved in another UK Research & Innovation (UKRI) project – called SUSTAIN Steel.  They had a small carbon dioxide liquefaction kit.  We have “borrowed” it and are using it to liquefy the captured carbon dioxide, albeit at a very slow rate.  We have other ideas for how to do this at a larger scale, but this works, and we are now capturing the required amount of carbon dioxide to send to the two centres where the next stage of our supply chain – the conversion of the carbon dioxide to ethylene oxide and dodecanol – will be carried out, but that’s another post!

So, what have we learnt?

Firstly, that project plans written in a hurry to fit within the proscribed timescale and budget will almost certainly be too optimistic and liable to require drastic adjustment.  This was no real surprise to those who had been involved in scaling up processes before, but we rediscovered the saying that “if it can go wrong, it will” is irritatingly true.  However, the capabilities of the individual organisations in the project and the creativity of the combined “leadership team” means that we have always found a way out of every “challenge”.  We have also applied to Innovate UK to extend the project by 4 months, and have been successful, so have bought a little more time.  The next work packages, which would have been squeezed by the 6 month (or so) delays will be “less” squeezed.

Perhaps the biggest learning is the need for flexible resources to enable scaling up the sort of processes we are using.  This does not necessarily mean expensive new buildings or plants.  A small carbon dioxide liquefaction plant that could handle 1-10 tonnes a day would have saved us about 2 months.  More engineering expertise in the consortium might have saved us another couple of months building and commissioning the FluRefin plant.  We had some allowance for creep in the original plan but when every month the deadline slipped by a month, I felt sorry for the project manager!

What has really been driven home to us is that the change we are attempting to prove – that it is feasible to move the chemistry supply chain away from virgin fossil carbon as a feedstock – may be scientifically credible, but reducing anything from theory to reality is harder than we think and required even more planning and effort than we imagined.

And we need to use realists, or even pessimists, as planners!!

Written by David Bott, Director of Innovation at SCI and originally published on Linkedin

BY DAVID BOTT

Science is hard work. Understanding the world around us well enough to predict the behaviour of everything from sub-atomic particles to planets requires insight, patience, imagination and rigour. But science also lays the foundations of many of the industries that have changed our world – from pharmaceuticals to airplanes.

It is this application of science to address societal challenges that benefits people. And one of the biggest challenges is moving away from using virgin fossil carbon to feed the chemical supply chain!

It is worth stating at this point that, as we have talked about this work, we meet many people who do not understand how the chemistry using industries underpin other supply chains. We have had to explain many times to disbelieving audiences that cleaning products are currently mostly made from oil!

At the moment, the many branches of the chemistry using supply chains start with about 2.6 billion tonnes of carbon dioxide equivalent produced from oil and gas extracted from the fossil reserves (about 5-6% of the carbon extracted annually goes into this use). There are other sources of carbon and the science to use them is proven, but we need to start development and implementation. This means designing and building manufacturing capacity that operates efficiently to produce the volume of material needed to satisfy the current and future market needs – and this is a lot!

Technology, Development, Innovation – whatever you call the process of turning science into products is also hard, but in a different way. Something may be scientifically possible, but to make a product out of it for less than the price people will pay for it and at a volume that all the people that want it will be satisfied can be difficult. And competing with an established route where the feedstocks are cheap and easily available, and the processes have been optimised and scaled over decades, requires tenacity.

Flue2Chem is an Innovate UK funded consortium of 16 organisations that could make up a wholly new supply that produces the materials we currently use at a large scale but without starting from virgin fossil carbon. Rather than trying to do everything all at once, it is focused on a single product – a surfactant that is widely used in a range of cleaning products. It is one way to re-imagine the future of those parts of chemistry based industries that currently use virgin fossil carbon as a feedstock. The project is focused on demonstrating that carbon dioxide can be collected from flue gases and, by a series of chemical steps, turned into that common surfactant. Although it is focused on a single product, the processes and the learning from scaling them up could be applied more widely.

Flue2Chem consortium members

The challenge of scaling-up

Making a lot of anything usually involves making it in a large factory – and the more product needed to satisfy the market demand, the larger the factory. We are mainly talking about chemistry here, so the core manufacturing unit is a reactor. In the laboratory, most people think that chemistry is done in test tubes, but the truth is that the most common reaction vessel is probably a sub 1 litre round-bottomed flask. This is where the science of the basic reactions is tested and optimised. The next step is then a vessel between 5 and 25 litres in size. This is where we first encounter scaling laws! If we make a reaction vessel which is twice as big in the linear sense, it has 8 (23) times the volume and 4 (22) times the surface area. Most chemical reactions involve either the absorption or emission of heat – the amount of heat (absorbed or generated) increases with the volume of the reaction, but the heat must move through the walls of the vessel. So, a reactor three times as big (the 1 litre to 25 litre example above) generates or absorbs 27 times the heat but it must move through 9 times the surface area. The reactor surfaces must be three times as thermally conductive to allow this. The 25 litre flask is often exactly the same design and made of the same material as the 1 litre flask, so this does not happen!

Given that chemical reactors can have a capacity up to 1,000,000 litres these are substantial size differentials! Here the ratio between the initial reactor and the final, at-scale reactor means the challenges for this simplest reaction parameter must change 1000 times.

And thermal management is not the only challenge. Mixing also requires more energy at larger scales; removing the by-products of the reaction is also more problematic as reactor size increases.

But working at large scale has some commercial advantages – the cost of capital equipment needed usually scales at a lower rate than the science gets hard, and the complexity of the ancillary equipment can also be optimised, making larger factories more commercially attractive. Since big factories are often more commercially attractive, the technological challenges have been worked on for decades and large reactors for the currently used reactions are well optimised!

This optimisation, or scaling-up of the process nearly always goes in steps, and the size of those steps depends on the confidence of those in charge! These days, a lot of these steps can be carried out using computer based process software – decades of scaling things up has given industry experience of and insight into the critical factors that need to be considered, but moving to new reactions means the basic information must be measured again!

And this is just to get it to work!

But how big should you make it? An important factor in determining the size of the reactor is the size of the market – and therefore how much product you need to make.

So, how much do we need to make to prove this new supply chain will work?

For most people, the scale of the chemistry based industries are not even recognised, let alone considered.

At present the petrochemicals industry, which provide the bulk of feedstocks to the chemistry based industries globally uses about 2.6 billion tonnes of carbon dioxide equivalent a year. To give an idea of scale, if all that was made into polyethylene (commonly used in packaging, toys and cars) it would be a cube just under a kilometre along each length.

As already described, the target molecule of Flue2Chem is a simple surfactant with a chain of 12 carbon atoms as the oleophilic (the bit that attaches to the dirt) end and 5 to 7 ethoxy units as the hydrophilic (the bit that dissolves in the water) end. It is widely used for all sorts of cleaning products – globally figures of around 17,600,000 tonnes a year are quoted. This is equivalent to about 44,000,000 tonnes of carbon dioxide equivalent – so about 1.7% of the global petrochemicals market! What sounds a lot rapidly becomes small when you look at the actual numbers!

And how is it playing out for the Flue2Chem supply chain?

When we started the project, we had two carbon capture streams – an established liquid based system capable of collecting 10 tonnes/day and a start-up solid state system with a capacity of 1 tonne/day. Given that we also had three sites from which to capture carbon dioxide and the plan was to run each for 30 days, that would have given us an input of just under a 1000 tonnes of carbon dioxide.

At the other end of the supply chain, the final assembly of the surfactant could be carried out at about 1000 tonnes and the consumer products companies could use all that output to carry out test marketing of at least three products.

We rapidly discovered that the bottleneck would be the chemistry to turn carbon dioxide into ethylene oxide (for the hydrophilic end of the surfactant) and dodecanol (for the oleophilic end). The thermo-catalytic routes might be able to make about a kilogramme of the ethylene oxide and probably much less of the dodecanol. And on the biotechnology side of the options, although there were companies making ethanol (a precursor to ethylene oxide) from flue gases, they were not using carbon dioxide as the source. Biotechnology routes are often attractive because they make a single product, but using the biobased route to dodecanol looks like it would be hard to make even a kilogramme.

This would give us a few problems, but as the project progressed, we ran into another challenge. The company with the liquid system decided to withdraw from active carbon capture in the UK (the subject of a later blog), and one of the carbon sources got a government grant to radically overhaul their plant to drastically lessen the amount of carbon dioxide they might produce, so they have “paused” their direct involvement in that part of the project. We had now gone from a capacity of 990 tonnes to 60 tonnes. This was still more than enough to keep the chemists happy, but it gave us another opportunity to be innovative. The two carbon dioxide sources were in Cumbria and North Ayrshire, but the chemistry to convert it was being carried out in Sheffield and Germany and the biology in North Yorkshire. How could we transport that amount of carbon dioxide? At about 1000 tonnes, it might have been possible to “rent” a bottling facility and install it at the capture sites. At less than 100 tonnes, the equipment did not even exist! The solution we are adopting is to pressurise about 3 kilogrammes of carbon dioxide in pressure vessels and transport it from site to site. This limit on how much carbon dioxide we can transport from the emitters to the converters puts another size restriction in place, so a sizable fraction of the carbon dioxide we capture will have to go back into the flue! This is not ideal, but given the goal is to validate a wholly new, more sustainable supply chain and the lack of any other options, we don't have much choice.

There will be more…

Stepping stones to wisdom – what have we learned?

Perhaps we should have checked our numbers before we submitted the proposal, but since any scale-up project is designed to see how difficult it is to scale-up, discovering that there are issues beyond the technological is good learning.

The chemical and biological restrictions are a result of the lack for scale-up facilities in the UK, and we currently have no other options. If we are to develop the new chemistries required to switch feedstocks away from virgin fossil carbon to carbon dioxide, waste biomass or recycled plastics and oils, we will need several levels of scale beyond those currently available.

Underpinning this last point is the fact that many do not understand how the chemistry using industries underpin other supply chains – even their own. We have had to explain the range of products made from virgin fossil carbon (IEA figures are plastics packaging 36%, upholstery, carpets and paints 16%, textiles 15%, home and personal car products 10%, pharmaceutical and agricultural products 11%, car interiors and tyres 7% and electrical 4%) many times and often find ourselves trying to convince disbelieving audiences that cleaning products are currently made from oil! This means that many in government do not see the need to invest at the national scale in them in a coordinated manner. Scaling-up chemistry is generally not well catered for.

Written by David Bott, Director of Innovation at SCI and originally published on Linkedin

BY DAVID BOTT

There is much talk of “decarbonisation” these days, and you could be forgiven for thinking this means eliminating carbon from all human activities. But there are lots of things that need carbon to exist. The chemistry of carbon is unique and nature relies on it for many things. Carbon has direct influence on conditions for life on our planet, whether or not you factor in the specific needs of human beings! And we depend on carbon chemistry for life too – our bodies burn carbon based fuels ourselves (grains, vegetables and meat are all carbon based materials).

We have also depended for millennia on carbon-based materials as clothing (skins, cotton and wool), housing (wood and thatch), and much more – until about 6000 BC when we started using inorganic materials (metals!) as well. With the birth of the oil age in the late 19th century, we started to make synthetic materials, initially striving to reproduce the properties of the natural materials we were used to – polyester was a cotton like material, polyamides were meant to be like silk, polyacrylonitrile was similar to wool in properties. In healthcare we started making naturally occurring therapies (like aspirin and morphine) at scale using synthetic chemistry. As we understood the relationships between chemical structure and properties during the 19th century, we moved on to more complex chemical structures. We cannot get away from carbon because so many planetary systems depend on it, so getting it rid of it altogether is not really an option!

So, what do we mean when we say “decarbonisation”?

The problem is not with carbon dioxide as such, but with the amount we have put into the ecosphere over the last 150 years or so years and the effect it is having on the climate.

In the past there was a lot more carbon than we currently have in the atmosphere – somewhere between 15-30 times as much – but then life wasn’t the same in the Mesozoic period – evidence suggests the average global temperature was 10-15 degrees higher, so species like us would probably not have survived. Over the intervening 150,000,000 years, a variety of natural processes absorbed and sequestered that carbon in rocks, coal, oil and gas. But coal, oil and gas are an easily available source of energy, and their extraction has powered progress over the last 200 years! And when we burn them, the carbon that was previously safety locked up in the ground goes back into the atmosphere.

So what is the problem?

The amount of carbon dioxide we have generated over the last 150 years can be found in the atmosphere, the oceans and on land. This is the product of the coal, oil and gas we have extracted and burnt over the same time period. The problem is that the Earth’s climate cannot cope with this increase, and we need to stop.

Here is how it all adds up:

Atmosphere – Since the beginning of the industrial revolution, the amount of carbon dioxide in the atmosphere has increased from around 2.2 to 3.3 trillion tonnes – meaning we have added about 1.1 trillion tonnes.

Oceans – There is a lot of focus on carbon dioxide in the atmosphere and the impact it has on climate, but carbon dioxide is also absorbed by the oceans, where it also has an impact – the water becomes more acidic and damages marine ecosystems. For every tonne of carbon dioxide in the atmosphere there is about 0.75 of a tonne in the oceans. This means there is probably about 800 billion tonnes in the oceans.

Land – There is also work that indicates that about 8.3 billion tonnes of plastic waste have been produced since 1950 – roughly equivalent to 26 billion tonnes of carbon dioxide. Since plastics account for about 30% of the petrochemical products stream, we can work out that 87 billion tonnes of carbon dioxide from the use of oil and gas as a feedstock is also in the ecosphere.

Total – This means we can estimate that we have put about 1.99 trillion tonnes of carbon dioxide into the ecosphere since we started using coal, oil and gas as a source of energy.

The amount that we find in the ecosphere is almost identical to the amount extracted from the geosphere over this time period. Evidence that this is a man-made effect can be seen by comparing this number to the 2.2 trillion tonnes of carbon dioxide equivalent that industry records show the coal, oil and gas industries have extracted from the planet over the last 150 years. The small difference is probably due to the accuracy of the figures, which have been collected over 150 years!

We often fall into the trap of differentiating between fossil carbon and biogenic carbon, as if biogenic carbon is acceptable, but we have been putting fossil carbon into the atmosphere for so long that it makes up about 35% of the carbon in the atmosphere and has therefore been absorbed by plants and will make up roughly the same fraction of what we call biomass! This means that 35% of the biogenic carbon is really second generation fossil carbon. This becomes important when one source is favoured over another by regulations.

The goal is not to stop using carbon – it is to stop taking it out of the ground and putting it into the ecosphere!

If the various government promises to achieve Net Zero are kept and we do manage to stop using fossil carbon as a fuel by 2050, where will we get the carbon we use as a chemical feedstock that we have come to rely on as the source of materials such as plastics, fertilisers, packaging, clothing, digital devices, medical equipment, detergents or tyres? Currently we use about 2.6 billion tonnes of carbon dioxide equivalent a year to make a wide variety of things – through a “petrochemical” supply chain. We cannot “decarbonise” that without inventing new materials to deliver all of the products, but we can “defossilise” it – which means we stop using virgin fossil carbon as its feedstock.

Where will the carbon come from then?

There are three sources of carbon (biomass, recycled plastics/oils/solvents and carbon capture and utilisation) widely touted as replacements for all that fossil carbon. All are essentially recycling previously used carbon. They tend to get framed as competitors for the role, but if you analyse the amounts available, the likely costs of using them, and the timescales needed to get them to the right scale it looks like we will need them all!

Back to Nature

Biomass refers to using biological sources for the raw materials – wood, crops, animals and bacteria are good examples. Advocates rightly point out that many synthetic materials are clones of natural materials. They tend to forget that society moved to synthetic analogues because there wasn’t enough to satisfy societies needs in terms of volume and price, but global supply chains were less sophisticated back then.

However, from the generally accepted numbers, there would be enough raw materials – the planet produces about 50 billion tonnes of biomass a year – of which about 14 tonnes is produced by man. Of that, it is estimated that about 1.8 billion tonnes of “waste” is produced a year – mainly cellulosic. This produced in farms and food processing plants. Of the biomass that goes to food, we waste about 30-40%, so can add another 1.6 billion tonnes, but this is produced in restaurants and houses, so collection might be expensive! And finally, we have the waste we humans and our animals directly produce. Estimates vary but are usually about 500 million tonnes of human waste and almost 3 billion tonnes from farm animals! There would be enough carbon in biomass to satisfy the requirements, but the logistics of collecting it might be a challenge (and probably involve the generation of more carbon dioxide – there is always a trade-off where transport is involved). Also, biological processes can often be slow and less atom efficient than the currently used chemical processes, but this can be accommodated by appropriate systems design.

Nevertheless, the use of biomass as a feedstock for chemicals is already here and growing in scale.

Second time around

All the carbon that currently goes out in the form of products could form the basis of a different recycling route – often called “chemcycling”. Here the previously used plastics, oils and solvents can be partially broken down into reactive chemical species like those used in the manufacture of the original products. This is usually done with heat, and so costs energy. It also often uses solvents or extra chemistry. Given the range of materials that will make up the input, there will probably need to be a sorting process at the front end. And, like the waste biomass, the input materials will be collected from geographically distributed sites, so will need to be transported to plants where the recycling will take place (with the potential carbon dioxide emissions as a result).

Mining the problem

Finally, we could use the largest source of carbon already in the ecosphere – the carbon dioxide we have been putting into the atmosphere. With its current concentration of about 0.05%, it is a daunting task. However, we can “practice” how to make it work with a higher concentration (often 10-15%) – when we burn things, we produce a gas stream with a higher concentration of carbon dioxide and send it up a chimney or flue. We will probably go on burning things for a few years yet and using them as a source of carbon will not only moderate the amount we put into the atmosphere in the short term, but also enable us to refine the technology so that we can one day we can remove carbon dioxide from the atmosphere and reverse the damage we have done to the climate – although sadly it would take hundreds of years to do so.

Are we there yet?

All three routes to providing a non-virgin fossil source of carbon are being worked on already. However, they are all at such a small scale it is difficult to judge their efficiencies and effectiveness.

• Biomass is probably the most technologically advanced, but scaling-up the processes and addressing the collection and logistics issues are important challenges that need to be overcome.
• Recycling the “second generation” carbon cannot supply enough – it is limited by the efficiencies and costs of all the processes from collection to chemical recycling but can probably contribute a sizable fraction of the requirement.
• Carbon Capture and Utilisation (CCU) is the least well advanced but with a roadmap to Direct Air Capture (DAC) (the slightly different name for capturing the carbon dioxide direct from the atmosphere) offers the most compelling argument for investment – if DAC can be made to work commercially, it can be used to remediate the atmosphere. Net zero targets aim to take us back to 1990 levels of carbon dioxide in the atmosphere by eliminating the use of fossil fuels. Depending on the scale and speed at which DAC can be implemented, it might be possible to get back to pre-Industrial Revolution atmospheric carbon dioxide levels in several hundred years!

Carbon Capture (CC) has rather had its reputation tarnished by the pervasive suggestion that it can be used to capture (and store) carbon dioxide so effectively we can go on using fossil fuels for many years. Most analysts outside the oil and gas industry do not see how the maths works!

All of the routes are years away from making a major contribution to replacing the volume of carbon based feedstocks used to make the wide variety of products (and the market is growing at over 5% per year, which means that it will double in size every 12 or so years). We need to start soon and grow quickly to make any meaningful impact.

Written by David Bott, Director of Innovation at SCI and originally published on Linkedin

BY DAVID BOTT

One of the questions we often get asked is ‘how did you assemble such a large project so quickly?’ The short answer is ‘we didn’t, it took years!’, but the story is important

In the last blog we discussed the scale of the use of petrochemicals to make things society doesn't know are made of fossil carbon, and the drive to change this – this time we will look at how we built the team.

On page 17 of the Chemistry Council Strategy published in 2019, you will find the phrase ‘Sustainable Materials for Consumer Products’. This is (we think) the first time the phrase was used in this context,. and so was effectively the beginning of the story.

Technically, there is prehistory. The UK government had tried twice before to understand and support the “chemistry-using” industries but had failed to capture the breadth and scale of their impact on the economy in their engagement. They had included the pharmaceutical companies alongside the more traditional “chemicals” companies, but not the extensive downstream activities that used chemicals to deliver a product or process. In 2018 they had spread their net a bit wider and included the consumer companies who use chemistry to make a large number of products for a whole range of markets. These companies were seemingly more aware of the way consumers were looking at the discussion on climate change and who were wondering why the products they could not live without had to be made from fossil carbon and contribute to climate change. So, these companies started making commitments to be fossil carbon free by 2030 or not long after. The scale of their production (often millions of tonnes) meant that the necessary changes to their supply chains had to be at a similar scale and they quickly found that their suppliers (and their suppliers) could not easily accommodate the changes they wanted to see in their chosen timeframe. What was required was a more radical rebuilding of their supply chains.

The Society of the Chemical Industry (SCI), who were responsible for the Innovation Committee of the Chemistry Council, decided to build a community who could do something about this challenge.

The first workshop in the area was held at SCI on 22 February 2020. It included participants from retailers (Marks & Spencer, Sainsbury’s, Walgreens Boots Alliance and Enkos), consumer products manufacturers (Unilever, GSK, Reckitt Benckiser and Proctor & Gamble) a number and variety of chemical manufacturers (Croda, Innospec, Johnson Matthey, Thomas Swan, BASF, INEOS, Lubrizol and Synthomer), universities/RTOs (CPI, University of Bath and University of York) and several companies engaged in the recycling of materials (Biffa, Symphony Environmental).

The discussion was outcome-oriented, and we finished the day with a draft list of things to work on in the second workshop. But within a few weeks COVID happened and we went into lockdown! As they learned to cope with Zoom and Teams, the core team met online and developed the ideas from the workshop. First, the tasks were sorted into three main buckets – engagement, new chemistries and measurement.

Talking to people

Under the engagement banner, we recognised the importance of explaining what we understood were the challenges and how best to address them. Audiences would include chemistry-based companies in the supply chain, regulators and policy makers in government, and consumers. Initial attempts at engagement rapidly taught us that before we could explain what we were doing, we often had to make the audience aware of the ubiquity of carbon-based chemistry in everyday life and the relationship to climate change. One example was when I found myself being interviewed by Rachel Johnson on LBC about the impact of laundry on climate change and her not believing that the cleaning products themselves were made from fossil carbon resources!

The idea of starting with awareness raising, moving on to (gentle) discussion of the science and technology before even mentioning the “ask” became our approach!

Changing the way we do things

The new chemistries banner was an area where we were all more comfortable. If we were to avoid using fossil carbon as a feedstock, we needed another source of carbon, or we needed to find the functionality the businesses needed using another element. The second option looked very difficult – and therefore expensive. The options for the first were well known – “biomass” (ill-defined but very popular as a choice), recycled (second generation?) plastics and oils (logistics is the current issue) and carbon dioxide (lots of it about, but more energy needed to get it to a useable state).

Then we agreed (being mostly from business) that we needed a specific target at focus on.

If we could start with a non-fossil source of carbon and turn it into a useful molecule, we would have demonstrated that there was a completely different way of making things. In the process we could learn what was possible, what impact this alternative would have on the environment, whether it was commercially viable and what social impact it might have.

Since there are so many things made of fossil carbon – packaging, paints, adhesives, textiles, carpets, upholstery, tyres, drugs, fertilisers, insulation and cleaning products – selection was difficult, but the team knew a lot about cleaning products, so we started there. After a lot of swapping of anonymised data, we alighted on non-ionic surfactants. They are extensively used in consumer cleaning products (about 1,000,000 tonnes a year) and they are relatively simple molecules. These are made up of a hydrophobic end (usually a 12-14 carbon atom chain) and a hydrophilic end (usually made up of 5-7 ethylene oxide units).

Alongside the search for a way to make this sort of chemical without using fossil carbon, we realised that cleaning products were almost invariably flushed down the drain – and that often that meant straight into streams and rivers. We knew from other studies that they would degrade into other chemicals, and eventually into carbon dioxide – but we could not find any studies that mapped the complexity of that degradation pathway – was it a biological process, or was it photolytic, or a mixture of both? We talked to BBSRC. We talked to NERC. To date we have not been able to interest any UK funding agency in researching this aspect of what happens to these carbon based molecules in the environment, although there is lots or research into the effect of the chemicals on the environment!

Measuring what was going on

The third area we pondered over was how to measure what was going on – both currently and as a result of anything we might do. We looked at various life cycle analysis studies and quickly realised there were real differences between academic studies – and even consultancy or in-house techniques. Given that we knew we would be building a wholly new supply chain, how were we going to measure the impact of our actions?

Getting on with it

We knew better what we had to do. The next problem was to find a way of funding the work. It took almost a year of talking to the KTN and Innovate UK before we became aware of the Transforming Foundation Industries competition. In the late Summer of 2021, we decided to develop a proposal to turn carbon dioxide from flue gases into our target surfactant.

The specification of the competition meant that we had to work with other foundation industries. Given that we wanted a source of carbon dioxide, and they mostly produce it, this gave us options. We built links to paper companies such as Holmen and UPM. They often use biomass boilers as heat and energy sources. These are currently classed as zero emissions under the emissions trading scheme, but the rules are tightening and are looking for the next technology to remain viable. We also talked to Tata Steel, who use coke both as a fuel and reducing agent in their blast furnaces. We tried to talk to cement manufacturers but were unsuccessful.

Next, we needed a means to capture the carbon dioxide in their flue gases. There are basically 3 ways to capture carbon dioxide, solvent adsorption, solid phase adsorption and membranes. We contacted Carbon Clean (who use solvents) and were already talking to the University of Sheffield (who were developing a solid phase process). Both were interested and so joined the consortium.

Turning carbon dioxide into the C12 fatty alcohol (to make the hydrophobic end of the surfactant) and the ethylene oxide (to make the hydrophilic end of the surfactant) was the next goal. The BASF, University of Sheffield and Johnson Matthey all had expertise in thermo-chemical processes which could achieve this and all were interested. We knew there would be biochemical processes that could achieve the same goal but no companies in the UK, so we turned to the Centre for Process Innovation (part of the High Value Manufacturing Catapult) and found they were working in the area so added them to the consortium.

Croda were already the supplier of choice to react these two components together to make the final surfactant.

We then had the consumer product companies, Unilever, Proctor & Gamble and Reckitt, who would evaluate the surfactant and “prove” that getting the carbon from a different source did not change the properties.

We also folded in our concerns about measuring the impact of what we had done by including the UKRI Interdisciplinary Centre for Circular Chemical Economy to evaluate the life cycle and technico-economic aspects of the various processes we were evaluating so that we could put together a justified case for a new supply chain at the end of project.

The Confederation of Paper Industries also joined to be able to understand what we had done and recommend it to other paper companies.

And the SCI joined to help with exploitation and dissemination as the project progressed.

Are we there yet?

We submitted our Expression of Interest to Innovate UK just before Christmas 2021 and (mostly) didn't worry about it until the New Year. On 10 January, we learned that our application was successful, so buckled down to writing the full application.

The consortium submitted its proposal on 6 April 2022

As we understand it there were eight proposals submitted but only money for four, but we were still disappointed that the initial funding announcement did not include us! However, somehow Innovate UK found some more money and the remaining projects were judged to be fundable so on 14 July we learned that we had the money!

For those who haven’t applied for Innovate UK funding before, the detailed process is simple but rigorous. One really, really important step is for every company to sign a “Collaboration Agreement”. This sets out the goals of the project, how it will be managed, and how the intellectual property that arises during the project will be allocated. It is often a source of contention, and the amount and intensity of the contention seems to scale geometrically with the number of partners in the consortium. Given that many of the partners were more used to competing than collaborating and they all had lawyers, it seemed at times to scale exponentially! However, because the scientific leads in all the companies had worked together (some, at this point, for over 3 years) and there was real commitment to get started, (after a small hiccup) we all signed the agreement just before Christmas 2022. It was then that we discovered we all had to sign the Grant Offer Letter as well, but we managed that too.

Then the work started…(see Part 3)

The exam question

So, how did we assemble the consortium?

1. It took time, and lots of interaction. The core of the consortium – Unilever, P&G, Reckitt, Croda, BASF, Johnson Matthey and the SCI – had all been sharing ideas, challenges, opportunities and frustrations for over 3 years. Individually some had also worked with the others we invited to join, so there were always personal recommendations and shared experiences.
2. It took transparency and honesty. The relationships we have built over those years are strong. We have disagreed (a fair amount) on the way, but we have always shared – and even strengthened through our interaction – a commitment to move from fossil carbon feedstocks to a sustainable chemistry based industry.
3. It required shared commitment, an understanding of how the different organisations fitted into what will be a wholly new supply chain, and tireless advocacy both within our own organisations – and to anyone who will listen outside them!
4. It needed the patience of a saint!

Written by David Bott, Director of Innovation at SCI and originally published on Linkedin

BY DAVID BOTT

A collaboration of 15 organisations is part way through an Innovate UK funded project to turn the carbon dioxide in flue gases into non-ionic surfactants for cleaning products. Many have asked: why we are doing it? how did we build the team? and how things are going? This is the first part of that story.

No one really thinks about the role of chemistry in society. Although everything around us is chemistry – life itself, the natural world, and the material world we have created to add to the natural world – we mostly talk about “chemicals” in a derogatory way. Does society understand how much it relies on carbon-based chemicals? Does chemistry need a PR agency?

Why we need carbon

It is difficult to say exactly when the “synthetic” world started, but the huge expansion came with the use of fractions of the oil and gas we were extracting from the ground as a fuel as material feedstocks about 120 years ago. The petrochemicals supply chain now accounts for about 2.6 billion tonnes of carbon dioxide equivalent a year (about 5.7% of the carbon extracted) and is growing at about 8% a year – therefore roughly doubling every 10 years. And the products at the end of the many supply chains that start with these fossil feedstocks range from things we cannot do without (such as disinfectants, soaps, textiles for clothes and so on) to things we “like” to have but would probably fight to keep (such as cosmetics and flying)!

The focus is often on single-use plastic packaging, which makes up about 30% of that 2.6 billion tonnes. But there are many other products that depend on the same source – products for use in the home (carpets, upholstery, paint and adhesives) at about 16%, textiles (mostly for clothes) at about 15%, pharmaceuticals, agrochemicals and fertilisers at about 11%, cleaning products and cosmetics at about 10%, the interiors of cars and their tyres at about 7% and the use in electrical and electronic products (both insulation and cases) at about 4%. Such is society’s use of these products, that we cannot simply stop using them, or make them from something other than carbon. We will need a source of carbon at the same scale.

At this point in the narrative, it is worth pointing out that although many uses of fossil carbon as a fuel can be replaced by alternative technologies, aviation fuel is different. Although there are prototype electric planes for short haul flights, and visions of hydrogen powered planes at some point, the options for long haul air travel look distinctly limited – with really only Sustainable Aviation Fuel as a runner. The aviation industry would need about 1.3 billion tonnes of carbon dioxide equivalent a year to keep going at their current rate, so about half that needed to supply our material needs. It faces the same challenge as the carbon based materials – if they do not use fossil carbon, where would it come from?

Where we can get carbon from

The source that gets talked about a lot is “biomass”. At the global level, it is estimated that about 100 million tonnes of biomass is produced each year, roughly half on the land and half in the sea. This equates to roughly 200 million tonnes of carbon dioxide equivalent. Most reviews discount the marine biomass as difficult to harvest and then calculate that of the land based only about 8 million tonnes (so, 16 million of carbon dioxide equivalent) a year can be harvested “sustainably”.

Another factor often quoted is the logistical cost of harvesting, since for some crops the energy required to harvest compromises the efficiency of the process. The factor that doesn’t get talked about much is the difference between the biological building blocks and the petrochemical ones we are used to – which would require us to build a different set of supply chains and result in products with different properties.

The second source is the materials made of fossil carbon we have already extracted. There are various estimates of how much plastic is in landfills, but the average seems to be about 5 billion tonnes of plastic – about 15 billion tonnes of carbon dioxide equivalent. This would need to be chemically recycled back to feedstocks equivalent to those that underpin the current supply chains.

The third source is the carbon dioxide we have been “storing” in the atmosphere. Since the start of the industrial revolution when our emission of carbon dioxide started in earnest, we have emitted close to 2.2 trillion tonnes of carbon dioxide – half of which is in the atmosphere and the rest has partitioned into the oceans. The problem is that it is very dilute, so you would have to capture a lot of “air” to get meaningful amounts of carbon dioxide – but people are trying!

However, since we are still burning a lot of fossil fuels (and biomass) at the moment, we have flues and chimneys where the carbon dioxide concentration is many times higher. Why not start there and increase the process efficiency with experience?

However, there is a challenge with using carbon dioxide as a source for carbon-based materials. Carbon dioxide is where carbon tends to end up in an oxygen-rich environment – particularly where there is light. It is basically at the bottom of a thermodynamic well and it needs a lot of energy – and green hydrogen – to get it back to those feedstocks we need to go on making things that we want in a way that keep the cost down.

What next?

So, we have a very large problem, some options – each of which has advantages and “issues”, and it will take a long time to change our supply chains, so we need to act fairly quickly before our filling the atmosphere with carbon dioxide does irreparable damage to our environment. We need a plan…

Written by David Bott, Director of Innovation at SCI and originally published on Linkedin

Following her insightful SCItalk on Diversity, Equality and Inclusion, Ijeoma Uchegbu, Chair in Pharmaceutical Nanoscience at UCL's School of Pharmacy speaks with Darcy Phillips.

Tell us about your career path to date.

I trained as a pharmacist and then did a PhD at the School of Pharmacy on drug delivery using nanosystems. After about two years of postdoctoral scientist work, I was appointed to a lectureship at the University of Strathclyde in Glasgow. After five and a half years, I was appointed to a professorship in 2002. I then joined the School of Pharmacy as a Professor of Pharmaceutical Nanoscience in 2006 and UCL in 2012.

My work has focused on understanding how drug transport may be controlled in vivo using nanoscience approaches. I co-founded Nanomerics Ltd. with my long-term collaborator – Professor Andreas G. Schätzlein – and next year will see Nanomerics take the technologies developed in academia into clinical testing. This is a huge milestone for our small company and for us personally. I liken this milestone to sending your only child off into the big wide world, and so we are understandably nervous and excited in equal measure!

Science was a refuge for me as I moved countries as a teenager – from London, the city of my birth, to a small town in Nigeria called Owerri. Science subjects were the only subjects that were common on the secondary school curricula of both countries. I really had no other option. I fell in love with science because it was familiar.

Which aspects of your work motivate you the most?

The joy of discovery really gives one a high and this is what I enjoy the most. Validation of one’s discoveries by other members of the scientific community cements the high and when one’s ideas are evidenced first by experimentation and then appreciated by one’s peers, there is no other feeling in the world quite like it.

What has been your proudest achievement?

Getting my professorship so soon after my appointment to a lectureship at the University of Strathclyde is up there with the greatest moments of my career, as is bringing up my daughters at the same time. Oh dear – there are far too many moments to mention, to be honest! Every day I don’t get a rejected paper or grant is really a proud day. Rejections are 90% of a scientist’s life.

You spoke recently at our SCItalk on diversity, equality and inclusion and the importance of data. Could you give us a summary on why this is so important?

To produce good quality science outputs with the maximum impact we need a variety of individuals asking and answering the most profound of research questions. We need more data on diseases and conditions that affect women and more data on the genomics affecting the global southern majority. We need answers to the pressing questions on health outcomes in the poorest in our UK society. Well, you get the picture. We need high quality data on these largely forgotten issues.

What do you think are the next key steps to making STEM more diverse and inclusive?

We first need to recognise that a problem exists. This is the first step. The data on underrepresentation needs to be at the forefront of our thinking when we are making decisions. We need funders to acknowledge the deficit in the current ways of doing things and then commit to act appropriately. The oddest thing about a skewed and unequal system is that we all lose out when there are entrenched inequalities. Even those that think that they are gaining from the current system are not.

Batteries are a critical enabler for reaching net zero. As their importance increases, so does the need to better understand how they operate.

Mel Loveridge, Associate Professor (Reader) at Warwick University, gives an overview of the complexities of battery science and how she is working to bring increased understanding to a wider audience.

As the role of batteries has an increasing presence in everyday life, there is now a focus on battery forensic science and advanced characterisation methods – a critical part of understanding the life of a battery, its safety aspects and its cycle life or lifespan.

This forensic analysis and advanced characterisation is the core part the work carried out by Associate Professor (Reader) Mel Loveridge at Warwick University, who says: ‘The aim is to firstly understand and identify early-stage signatures of battery degradation, and ultimately to unearth the root causes and propagation of failure in lithium-ion battery (LIB) components.’

Since LIBs were commercialised in 1991, the electronic devices that use LIBs have diverged considerably, with much larger format batteries now required to electrify transport. This is a critical enabler that is needed if the world is to reach net zero.

‘Much research is focused on developing materials with higher energy and power density to effectively do this, and this is why battery safety considerations are more paramount now than ever,’ says Loveridge.

‘It is only by understanding how materials (electrodes and electrolyte) degrade using sophisticated forensic techniques, that we can feedback into the design of better, safer, more robust and stable components that will last longer,’ she adds.

This is key for the continued range and power improvements in electric vehicles, where ultimately everyday users will benefit from advances in battery materials and manufacturing processes.

Developing characterisation capabilities

This understanding requires effective characterisation capabilities to look at the chemical and structural dynamics that occur inside the battery as it ages. This can be accomplished destructively by autopsy when the battery has reached the end of its life (ex-situ) or done in real time whilst the battery is going through charge-discharge cycling (operando).

Because of the small size of the lithium atom, specialised X-ray based microscopy and other techniques are required to detect and map it. Fully understanding the complex journey of the lithium ions during battery operation is still challenging for the battery community.

Pictured above: A cathode particle. Copyright WMG

To facilitate this greater understanding, WMG was recently awarded an equipment grant to build the UK’s first multi-modal microscope platform with a plasma focused ion beam sectioning device (deliberately designed with batteries in mind, unlike other systems in existence). This includes a time-of-flight mass spectrometer to enable 3D detection and mapping of lithium. The integrated analytical platform will allow us to understand micro to meso scale structure and chemical dynamics over broad length and time scales.

The recent EU 2030 roadmap (Battery 2030+) stated “The accelerated discovery of stabilised battery materials requires special attention to the complex reactions taking place at the many interfaces within them.” Also awarded was a Lord Bhattacharyya PhD project to work on the commissioning and further development of this characterisation platform.

Breaking down the complexity for government and media

The work is highly challenging and riddled with complexities, but it has attracted significant media and government interest in the last decade and Loveridge has been one of the voices providing accessible, expert insight on a range of media platforms.

‘I have been fortunate to be interviewed for BBC2, Channel 4 and BBC Radio 4, describing how batteries work. I have also participated in energy-related panel discussions with the House of Lord’s Science & Technology Committee and the House of Commons Shadow Cabinet. Prior to this, an article I published on the temperature implications of wireless charging for a mobile phone battery was summarised in a feature in The Telegraph.’

The important work being carried out in battery forensic analysis is set to shape the future of battery technology.

We catch up with Zoë Henley, a Medicinal Chemistry Lead at GSK and recent recipient of a Rising Star Award in the category of Science & Engineering

Tell us about your career path to date.

Growing up, I loved science and have early memories of playing with my beloved chemistry set. However, it wasn’t until my A-levels that I knew I wanted to study chemistry at university. I had an inspiring chemistry teacher who supported me to apply, and I ultimately gained a first-class MSci chemistry degree from the University of Bristol.

I joined GSK as an Associate Scientist in 2006 and in my early career I was focused on identifying new molecules to treat respiratory diseases. As a chemist, I use my synthetic and medicinal chemistry skills to identify potential drug candidates, one of which reached Phase 2 clinical trials in patients for the treatment of Chronic Obstructive Pulmonary Disease, which is a life-threatening lung condition with no current cure. I have also led discovery efforts on early-phase research projects to validate the exact role a potential therapeutic target plays in a disease, which is critical for initiating a drug discovery programme.

Through my work, I developed deep technical skills in inhaled drug design and was appointed chair of a technical network for inhaled drug discovery programmes within GSK.

Alongside my work in the laboratory, I also developed my technology skills to become the lead user in Europe for drug compound design and data analysis software.

I was promoted to a Scientific Investigator in 2013 and achieved my PhD in 2014, through a collaborative programme between GSK and the University of Strathclyde. In September 2021, I was promoted to Team Leader.

Over the period I have been a team leader, I have supported 12 scientists and have had the opportunity to mentor graduate chemists and supervise one-year industrial placement students. I am currently a project Medicinal Chemistry Lead and have three direct reports who I support in their professional and scientific development at GSK.

‘I am passionate about science and the job that I do, and am committed to being an advocate for female leaders in chemistry.’ Image: Zoë Henley

Which aspects of your work motivate you the most?

I find the job of a medicinal chemist fascinating and highly rewarding. As a chemist, I have the opportunity to make the molecule that becomes a medicine to help patients, and this is my greatest motivation. Medicinal chemistry is a fast-paced, constantly evolving field that requires diverse skill sets. I find it refreshing to work within a diverse team, in particular working internationally across our global organisation, where I have had experience of working with colleagues across scientific disciplines and from different cultures and backgrounds who bring varied perspectives.

You were recently recognised with a Rising Star Award in the category of Science & Engineering, do you have any advice for anyone starting out their career in this field?

I am passionate about science and the job that I do, and am committed to being an advocate for female leaders in chemistry. For those starting out in this field, I would encourage them to follow their hearts and make well-informed career and personal choices to fulfil their dreams. Whenever I have had decisions to make, I have relied on close friends and mentors for advice, and I would encourage others to identify role models and seek their mentorship. I would also advise pursuing anything you feel passionate about. This might mean, for example, developing a new skill or gaining deeper expertise.

‘GSK as an organisation is highly supportive of flexible working, and within my own department I have continually had support for my professional development, in particular when I returned to work after one year maternity leave.’ Image: Zoë Henley

You’ve been working at GSK for a number of years now – can you tell us a bit more about how they’ve supported you in your career and allowed you to balance this with family life?

Throughout my career at GSK I have had so many opportunities to develop professionally and personally. Alongside continuously developing my technical skills, I have been able to carry out a PhD whilst still a full-time employee of GSK, participated in STEM outreach activities, had supervisory responsibility for both GSK employees and PhD students on collaborative projects, and I have been asked to take leadership roles in many different settings.

In 2019, I became mum to my son Sam, and I have since progressed my career whilst working part-time. I had very few female role models until I came to GSK, where the number of female chemists is high and there were many who had families and successful careers, which gave me confidence that I could have the same.

GSK as an organisation is highly supportive of flexible working, and within my own department I have continually had support for my professional development, in particular when I returned to work after one year maternity leave. My manager was highly supportive of my continued trajectory towards taking a leadership role and supported me in applying for a Deep Dive Career Programme at GSK, which is a competitive programme for future leaders who want to actively shape their career journey.

The programme allowed me to set out a detailed personal development plan and helped to expand my network. The leaders of my department also offered me managerial responsibilities, and this ultimately empowered me to apply for and achieve a Team Leader position.

I have a successful career/family life and aim to give other chemists the confidence that they can achieve the same.

If you'd like to hear more from inspiring female scientists like Zoë take a look at our upcoming SCItalk on Wednesday 27 September: Women in STEM: Better Science and a Better Workplace for Everyone.