29 April 2021
3rd SCI-RSC Symposium on Transporters in Drug Discovery and Development
Organised by:
SCI's Fine Chemicals Group, RSC’s Biological and Medicinal Chemistry Sector and the Drug Metabolism Discussion Group (DMDG)
Online webinar: 10:30 BST
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Synopsis
Cell surface transporters play a key role in human health and disease, both through their impact on drug disposition and as therapeutic targets in their own right. This third meeting in the series will feature talks on transporter structural biology, the impact of transporters on ADME and biodistribution, transporters as therapeutic targets and other aspects of transporters relevant to drug discovery and development
Attendees
Bringing together leading exponents in the field from industry and academia, the meeting will appeal to medicinal chemists, DMPK scientists and other workers interested in the impact of transporters on human health.
Programme
Morning session
- 10.30
- Opening remarks
- 10.40
-
Calculation of an In Vitro Apical Efflux Ratio from P-glycoprotein (P-gp) - Impact on Screening and Compound Optimization
Carina Cantrill, Roche - 11.10
- PBPK of transporter-mediated hepatic disposition using the imaging biomarker gadoxetate
Daniel Scotcher, University of Manchester - 11.40
- Break
- 11.50
- Transporter PBPK modelling and DDI
Venkatesh Reddy, AstraZeneca, UK - 12.20
- Heteromeric amino acid transporters: disease and structure
Manuel Palacin, Institute for Research in Biomedicine, Spain - 12:50
- Lunch break
Afternoon session
- 14:00
- Structural insight into substrate and inhibitor interactions with human multi-drug transporters ABCB1 and ABCG2
Kaspar Locher, ETH Zurich, Switzerland - 14.30
- Malarial Transporters
Jeremy Burrows, Medicines for Malaria Venture, Switzerland - 15:00
- Break
- 15.10
- Discovery of macrocyclic peptide inhibitors of bacterial LPS transport
Evan Green, Genentech USA - 15.40
- Plenary Address: Genomics of Transporters: Informing drug development
Kathy Giacomini, UCSF - 16.30
- Closing remarks
- 16:40
- Meeting close
| Before early bird (ends Monday 15 March) |
| £85 SCI/RSC/DMDG* member |
| £115 Non-member |
| £45 SCI/RSC/DMDG* student member |
| After early bird |
| £135 SCI/RSC/DMDG* SCI member |
| £175 Non-member |
| £45 SCI/RSC/DMDG* student member |
*RSC and DMDG members should email their name, organising body and membership number to conferences@soci.org in order to receive the relevant code to book for this event.
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Sponsorship
For further information on sponsorship packages and prices, please email conferences@soci.org.
Organising Committee
- Emmanuel Callens, Selcia
- John Cumming, Roche
- Jamie Henshall, UCB
- Fabien Lecomte, UCB
- Martin Lowe, UCB
- Mohammed Ullah, UCB
Conference Team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
