15 October - 16 October 2024

Targeting protein degradation 4

Organised by:

SCI’s Fine Chemicals group and RSC’s Biological and Medicinal Chemistry Sector

Cranfield University, UK

Registration Closed

This event is no longer available for registration.

Synopsis

One of the most exciting new therapeutic modalities to emerge in the 21st century has been Targeted Protein Degradation (TPD). In 2021, the Targeted Protein Degradation Market size was valued at USD 400.5 million and is poised to grow from USD 507.0 million in 2022 to USD 3,300.0 million by 2030 and so has attracted interest from academia, non-profit organisations through to CROs and small and large pharma.

This multidisciplinary meeting aims to present the latest developments in the design, biology, chemistry and ADME in TPD within the general themes of PROTACS (including non-oncology targets), Molecular Glues and non-PROTAC degraders. We aim to highlight the newest in enabling technologies such as computational techniques, Direct to Biology, HT synthesis (click, photochemistry etc) and structural biology methods.

Attendees

The meeting aims is targeted at academic and industrial scientists engaged in all aspects of research into the ubiquitin proteasome pathway and those interested in broadening their knowledge in this rapidly expanding field.

Call for oral and poster presentations

Submissions for oral and/or poster presentations are welcomed around the conference general themes. Abstracts should be maximum 300 words indicating title, authors, institution and preference for presentation option (Oral presentation and/or Poster) and sent to conferences@soci.org with the subject line “Targeting Protein Degradation 2024 - abstract submission”. Presentation slots are inevitably limited and will be allocated to achieve a balanced programme. Prizes will be awarded for the best presentation and poster. An abstract template can be downloaded here.

Deadline for oral presentations - Friday 31 May 2024 (decisions by end of June)
Deadline for poster presentations - Friday 30 August 2024

Exhibition and sponsorship

For further information and prices, please email conferences@soci.org.

Existing Exhibitors
Bioascent Discovery
Charnwood Discovery
Selvita
MedChemica

Existing Sponsors
AstraZeneca
GSK
Apex Molecular
Evotec
Concept Life Sciences
Croda

Programme

Tuesday 15 October 2024

09.45: Registration
10.25: Opening Remarks
10.30: Plenary lecture: Gazing into the crystal ball - what have we learnt and where does TPD research need to go next?
Ian Churcher, Janus Drug Discovery Consulting
11.10: Discovery of Novel Small Molecules Binders of Soluble Mutant HTT and Derivatization into PROTACs
Geoffrey Schwertz, UCB
11.35: Discovery of BclxL protein degraders for overcoming cancer resistance
Jim Sheppeck, AZ
12.00: Targeting cancer with panKRAS degraders
Vesna Vetma, Centre for Targeted Protein Degradation, Dundee
12.25: Lunch
13.30: Photocatalysis enabled One-Pot PROTAC Library Synthesis
Jacqueline Bitai, Boehringer Ingelheim
13.55: Exploring the Pharmacokinetics of PROTACs: A Focus on Solubility and Metabolic Stability
Gabriele Cruciani, University of Perugia
14.20: CRBN-midi: expanding the toolbox for structural and biophysical characterization of protein degraders
Alena Kroupova, Centre for Targeted Protein Degradation, Dundee
14.45: Leveraging XChem Crystallographic Fragment Screening and Chemist-Assisted Robotics for Silent Hotspot Mapping and Rapid Fragment Expansion
Ryan Casement, Centre for Targeted Protein Degradation, Dundee
15.10: Refreshments and exhibition
15.40: Making it stick – how can we convert inhibitors into molecular glue degraders?
Ben Bellenie, ICR Centre for Protein Degradation
16.20: Identification, optimization and characterization of Cyclin K molecular glue degraders
Douglas Thomson, Proxygen
16.45: Degradation of BRD9 by a novel targeted glue
Wojciech Stec, Amphista Therapeutics
17:10: Flash poster presentations
17.30: Poster presentations and networking drinks (till 18:10)
19.00: Conference Dinner

Wednesday 16 October 2024

09.00: Refreshments and exhibition
09.15: Plenary lecture: Molecular mechanisms and rational design of protein degraders
Alessio Ciulli, Centre for Targeted Protein Degradation, Dundee
09.55: Development and Application of Direct-to-Biology for High-Throughput PROTAC Synthesis and Testing
Rob Law, GSK
10.20: RSC BMCS Hall of Fame Award and Lecture: A career doing STUFF
Mike Hann, GSK
11.00: Refreshments and exhibition
11.30: Enabling targeted protein degradation in bacteria
Ester Morreale, Crick Institute
11:55: Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of “undruggable” targets
David Selwood, University College London
12.20: Structural Insights into PROTAC Handle Development for the Cullin-2 Substrate Adaptor KLHDC2
Melissa Sweeney, University of Oxford
12.45: Lunch
13.45: Plenary lecture: Targeting chromatin regulatory proteins with therapeutic degraders
Danette Daniels, Foghorn Therapeutics
14.25: Discovery of novel degraders for TPD applications operating through a CUL1/SKP1 SCF complex
Mat Calder, Phoremost
14.50: PROTAC-based approach to develop broad-spectrum antiviral agents triggering the proteolysis of the major viral protease
Alessia De Santis, University of Florence
15.15: Activin Receptor-like Kinase 2 Degradation as a Novel Therapeutic Strategy Towards the Treatment of Diffuse Intrinsic Pontine Glioma
Daniel Webb, Charles River Laboratories
15.40: Closing Remarks

SCI’s Fine Chemicals Group are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with full inclusivity where attendees from all backgrounds are welcome. We are open to offering flexible presentation options.

Accessibility Grants

SCI accessibility grants are available to support SCI members with disabilities, long term health conditions, those who require a carer, and members who are nursing parents to attend SCI events. Download an application form to apply for a grant.

Accommodation

Rooms onsite are available on a limited basis so booking early is recommended.

SCI’s Delegates require accommodation will need to email venuecranfield@cranfield.ac.uk or call 01234 754341 and quote Society of Chemical Industry, reference 395664 in order to receive the rates offered to you. Upon reservation guests will be asked to provide payment.
If the guest wants to hold a specific room (twin, accessible etc.) it will need to be asked at time of booking otherwise the reservation will be made on a run of house basis and we cannot guarantee availability at time of check in.

Mitchell Hall

https://venuecranfield.co.uk/mitchellhall/

Single room with breakfast: 108.00 per night, per room
Double room with breakfast: £135.00 per night, per room

CMDC

https://venuecranfield.co.uk/cmdc/

Single room with breakfast: 108.00 per night, per room
Double room with breakfast: £135.00 per night, per room

Should you not be attending the conference dinner, there is a restaurant available at each hotel where you can purchase food and beverages.

Venue and Contact

Cranfield University

Located in: Cranfield University
College Road
Cranfield
Bedfordshire
MK43 0AL

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org

Fees

Early bird - ends Tuesday 10 September 2024
SCI/RSC Member - £215
Non-member - £295
SCI/RSC Student Member - £135

After early bird
SCI/RSC Member - £260
Non-member - £345
SCI/RSC Student Member - £185

Conference dinner
There will be a dinner available for delegates on the first night. This provides a valuable networking experience.
Places are available as 'optional extras' at £60 pp based on 3 x course meal and drinks included.

*RSC members should enter the Event discount code EJRFCHEM235 and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration.

*RSC student members should enter the Event discount code EJRFCHEM235S and select "Guest member" under the section member type. Delegates will be contacted for their membership number after successful registration.

All registrations will automatically receive a confirmation within 24 hours of registering for the event. Should you not receive written confirmation of your booking, please email conferences@soci.org

Become an SCI Member and save on this and future events

See Membership Options

Booking Process/Deadlines

Booking terms and conditions

Travel information

Cranfield University is well situated for access by road and rail (via Bedford and Milton Keynes). Taxis and buses are available from Bedford and Milton Keynes stations to the University. For air travellers, Bedford mainline railway station directly connects to Luton and Gatwick airports, Milton Keynes serves Birmingham International. Those travelling via Heathrow will need to travel into central London and from there onto Bedford or Milton Keynes.

For more details please see the link here.

Free transport will be provided for delegates to Bedford or Milton Keynes railway stations after the meeting. Please select abox to confirm which station you would required transport to when registering for the event.

Recommended taxi service

https://www.skylinetaxis.co.uk/

Bursaries

A limited number of bursaries are available for students as a contribution to the cost of registration fees, travel and accommodation. For more information and to receive an application form, please contact conferences@soci.org with “Targeting protein degradation 4’ in the title.

Partners

Exhibitors

Organising committee

Sean Bew, UEA
Stuart Cameron, Concept life sciences
Nicola Chessum, Boehringer-Ingelheim
Katherine Jones, Charles River
Suzanne O’Connor, University of Dundee
Hannah Woodward, MSD