Novel signalling mechanisms regulating platelet activation and thrombosis

Synopsis

Platelets are highly reactive fragments of megakaryocytes that play a central role in thrombosis and haemostasis. They have also been implicated in wound repair, inflammation and immunity, and blood/lymphatic vessel separation. However, it remains unclear how the number and reactivity of platelets in the circulation is regulated. Recent findings from the Senis lab have identified the receptor-like protein-tyrosine phosphatase CD148 and the immunoreceptor tyrosine-based inhibition motif-containing receptor G6b-B as critical regulators of the threshold of platelet activation and platelet homeostasis. Professor Senis will discuss what lead his group to investigate these receptor-like proteins in platelets, how they modulate platelet reactivity and thrombosis, and their potential as novel anti-thrombotic drug targets. 

Speaker

Professor Yotis Senis, Cardiovascular and Respiratory Sciences, University of Birmingham

Programme

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