14 April - 15 April 2021
37th Process Development Symposium 2021
Organised by:
SCI's Fine Chemicals Group
Online Webinar
Registration Closed
This event is no longer available for registration.
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Synopsis
Process Development is the application of chemistry to the scale up of new synthetic processes from the laboratory, through pilot plant to full-scale commercial manufacture and into life cycle management. It is an extremely broad discipline, crossing the boundaries between synthetic organic chemistry, process technology and chemical engineering. The area of Process Development continues to be a challenging and important area for the research into and application of modern synthetic organic chemistry, as well as enabling technologies.Attendees
The symposium aims to bring together a wide range of speakers from across the Pharmaceutical, Agrochemical and Fine Chemical industries, as well as from an academic background. This meeting brings together experts from across the entire spectrum of the discipline to present state-of-the-art process development.Programme
Day 1 - Wednesday 14 April
09:00 Welcome and introduction to day 1
09:05 Site-specific and enantioselective sp3 C-H functionalization
Prof Guosheng Liu, SIOC, China
09:50 Analytical techniques for process understanding: established and novel approaches to reaction monitoring
Dr Maria Ciaccia, Syngenta, UK
10:30 Break
10:50 Experimental design and its place in process development
Dr Laura Forfar, Catalysis Consulting Ltd, UK
11:35 Regioselective preparation and functionalization of azoles for the synthesis of active
pharmaceutical ingredients
Dr Simon Wagschal, Janssen Pharmaceutical Companies of Johnson & Johnson, Switzerland
12:15 Lunch
13:15 Development of late-stage difluoromethylation methods for the synthesis of a CDK2/4/6 inhibitor
Dr Shengquan Duan, Pfizer, USA
14:00 Process development of a robust manufacturing route for sugammadex
Dr Sue Zultanski, Merck, USA
14:40 Break
15:00 Process development in the synthesis of CF corrector VX-661
Dr Cristian Harrison, Vertex pharmaceuticals, USA
15:45 Process chemistry award winner 2020: Design, development and applications of
catalytic synthesis methods based on phosphorus and silicon
Prof Ross Denton, University of Nottingham, Academic award winner, UK
16:25 Closing remarks
16:30 Close of the day
Day 2 - Thursday 15 April
09:00 Welcome and introduction to day 2
09:05 Particle design and modelling technologies for API manufacturing
Dr Claire Wombwell, Johnson Matthey, UK
09:50 New perspectives: approaches for the application of metal scavengers to impurity
control in pharma
Dr Sunil Rana, Biotage GB Ltd, UK
10:30 Break
10:50 Probing reagent / catalyst (dis)function
Prof Guy Lloyd Jones, University of Edinburgh, UK
11:35 The application of C-H functionalisation in the development of a concise and convergent route to nemiralisib
Dr Katherine Wheelhouse, GlaxoSmithKline, UK
12:15 Lunch
13:15 Right particle journey: crystallisation process development from labs to scale to
support drug product processing
Dr Rachel Sullivan, AstraZeneca, UK
14:00 An enantioselective total synthesis of (+)-duocarmycin SA
Dr Michael Schmidt, Bristol Myers Squibb, USA
14:40 Break
15:00 Automation and autonomy to enable process chemistry
Prof Jason Hein, University of British Columbia, Canada
15:45 Application of transition-metal catalysis, biocatalysis and flow chemistry as
state-of-the-art technologies in the synthesis of LCZ696
Dr Florian Kleinbeck, Novartis, Switzerland
16:25 Closing remarks
16:30 Close of the day
Fees
| Before early bird (ends Monday 15 March) |
| £150 SCI member |
| £200 Non-member |
| £75 student member |
| After early bird |
| £250 SCI member |
| £310 Non-member |
| £75 student member |
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Booking Process/Deadlines
CPD information
SCI Members attending this meeting are able to claim CPD points.
Sponsors
Organising Committee
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Louis Diorazio, SCI/AstraZeneca
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Max Espensen, Pharmaron
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Stella James, SCI/Bionow
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Dave Lathbury, SCI/Astute Chemical Development Ltd
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David Pascoe, SCI/GlaxoSmithKline
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Hazmi Tajuddin, SCI/Syngenta
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Robert Walton, SCI/Pfizer
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Hilmar Weinman, Janssen Pharmaceutical Companies of Johnson & Johnson
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Andy Wells, Charnwood Technical Consulting Ltd
Exhibition and Sponsorship
For further information and prices please email jacqui.maguire@soci.org
Conference team
Tel: +44 (0)20 7598 1561
Email: conferences@soci.org
